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Titolo:
Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions
Autore:
Kanungo, J; Pratt, SJ; Marie, H; Longmore, GD;
Indirizzi:
Washington Univ, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 v, Dept Med, St Louis, MO 63110 USA Washington Univ, Dept Cell Biol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 t Cell Biol, St Louis, MO 63110 USA Univ Coll London, Dept Physiol, London WC1E 6BT, England Univ Coll LondonLondon England WC1E 6BT ysiol, London WC1E 6BT, England
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 10, volume: 11, anno: 2000,
pagine: 3299 - 3313
SICI:
1059-1524(200010)11:10<3299:AACLPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CONTACT PROTEIN; EARLY XENOPUS EMBRYOS; ADHESION COMPLEX; SH3 DOMAIN; CATENIN; KINASE; ZYXIN; ACTIVATION; CADHERINS; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Longmore, GD Washington Univ, Dept Med, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 St Louis, MO 63110 USA
Citazione:
J. Kanungo et al., "Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions", MOL BIOL CE, 11(10), 2000, pp. 3299-3313

Abstract

Cellular adhesive events affect cell proliferation and differentiation decisions. How cell surface events mediating adhesion transduce signals to thenucleus is not well understood. After cell-cell or cell-substratum contact, cytosolic proteins are recruited to clustered adhesion receptor complexes. One such family of cytosolic proteins found at sites of cell adhesion is the Zyxin family of LIM proteins. Here we demonstrate that the family member Ajuba was recruited to the cell surface of embryonal cells, upon aggregate formation, at sites of cell-cell contact. Ajuba contained a functional nuclear export signal and shuttled into the nucleus. Importantly, accumulation of the LIM domains of Ajuba in the nucleus of P19 embryonal cells resulted in growth inhibition and spontaneous endodermal differentiation The differentiating effect of Ajuba mapped to the third LIM domain, whereas regulation of proliferation mapped to the first and second LIM domains. Ajuba-induced endodermal differentiation of these cells correlated with the capacity to activate c-Jun kinase and required c-Jun kinase activation. These resultssuggest that the cytosolic LIM protein Ajuba may provide a new mechanism to transduce signals from sites of cell adhesion to the nucleus, regulating cell growth and differentiation decisions during early development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:20:59