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Titolo:
Changes with aging in the modulation of macrophages by norepinephrine
Autore:
Ortega, E; Garcia, JJ; Saez, MC; De la Fuente, M;
Indirizzi:
Univ Extremadura, Dept Physiol, E-06071 Badajoz, Spain Univ Extremadura Badajoz Spain E-06071 t Physiol, E-06071 Badajoz, Spain Univ Complutense, Fac Biol Sci, Dept Anim Biol Anim Physiol, E-28040 Madrid, Spain Univ Complutense Madrid Spain E-28040 nim Physiol, E-28040 Madrid, Spain
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 3, volume: 118, anno: 2000,
pagine: 103 - 114
SICI:
0047-6374(20000929)118:3<103:CWAITM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERITONEAL-MACROPHAGES; IMMUNE-SYSTEM; STRESS; AGE; CHEMOTAXIS; CATECHOLAMINES; PHAGOCYTOSIS; MECHANISMS; ADHERENCE; EXERCISE;
Keywords:
aging; macrophages; norepinephrine; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ortega, E Univ Extremadura, Dept Physiol, Ave Elva S-N, E-06071 Badajoz, Spain Univ Extremadura Ave Elva S-N Badajoz Spain E-06071 ajoz, Spain
Citazione:
E. Ortega et al., "Changes with aging in the modulation of macrophages by norepinephrine", MECH AGE D, 118(3), 2000, pp. 103-114

Abstract

The effect of aging on the norepinephrine (NE)-induced modulation of phagocytic and oxygen-dependent microbicidal processes of mouse peritoneal macrophages was studied. Phagocytosis of latex beads on culture plates and superoxide anion production was evaluated in young (12 weeks), adult (22 weeks),mature (48 weeks) and old (72 weeks) BALB/c mice after in vitro incubationwith 10(-12), 10(-9), 10(-7), 10(-5) or 10(-3) M concentrations of NE. Theresults indicate that the phagocytic response to NE is quite similar in young and mature mice, with increased phagocytosis after incubation with 10(-7) and 10(-3) M, and decreased phagocytosis with 10(-5) M. Macrophages fromadult mice increased their phagocytic capacity after incubation with the highest concentrations of NE (10(-5) and 10(-3) M) and macrophages from old animals only were stimulated with 10(-3) M. In addition, it was found that usually NE increased the extracellular superoxide anion production in the absence of phagocytosis in adult mice. No statistically significant changes were found in intracellular superoxide anion levels, but an increase was seen after phagocytosis in macrophages from adult, mature and old animals, especially after incubation with 10(-5) M. In conclusion, the results obtained indicate that the modulation of macrophages by NE does not only depend onthe concentration of this neurotransmitter, but also on age. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:46:04