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Titolo:
Up-regulation of bradykinin response in rat and human bladder smooth muscle
Autore:
Sjuve, R; Boels, PJ; Uvelius, B; Arner, A;
Indirizzi:
Univ Coll, Inst Child Hlth, Dept Physiol Sci, Vasc Biol & Pharmacol Unit, London, England Univ Coll London England i, Vasc Biol & Pharmacol Unit, London, England Univ Lund, Dept Urol, S-22100 Lund, Sweden Univ Lund Lund Sweden S-22100Univ Lund, Dept Urol, S-22100 Lund, Sweden
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 5, volume: 164, anno: 2000,
pagine: 1757 - 1763
SICI:
0022-5347(200011)164:5<1757:UOBRIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; INFRAVESICAL OUTFLOW OBSTRUCTION; RABBIT URINARY-BLADDER; INDUCED CONTRACTION; GUINEA-PIG; IN-VIVO; MOTOR-RESPONSES; B-1 RECEPTORS; DNA-SYNTHESIS; DETRUSOR;
Keywords:
hypertrophy; rats; human; bradykinin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sjuve, R Univ Coll, Inst Child Hlth, Dept Physiol Sci, Vasc Biol & Pharmacol Unit, London, England Univ Coll London England iol & Pharmacol Unit, London, England
Citazione:
R. Sjuve et al., "Up-regulation of bradykinin response in rat and human bladder smooth muscle", J UROL, 164(5), 2000, pp. 1757-1763

Abstract

Purpose: Responses to bradykinin were investigated in vitro in isolated control and hypertrophic smooth muscle strips from rat bladder. Materials and Methods: Bladder hypertrophy was induced by a 10-day period of partial urinary outflow obstruction. In addition, human bladder strips were also investigated. Results: Bradykinin (1 nM. to 1 mu M.) caused contractions in all tissues studied. In the freshly isolated rat bladder preparations bradykinin induced contractions were similar and of small amplitude in control and hypertrophic tissues. After a 4-hour equilibratory period contractile responses to bradykinin and the B1 specific bradykinin receptor agonist desArg(9) bradykinin were slightly increased in the controls but there was approximately a 6-fold increase in the hypertrophic muscle strips. After 4 hours of equilibration the human bladder strips showed a smaller but still significant increase in contractile response to bradykinin. Indomethacin, a cyclooxygenase inhibitor, almost abolished the increased response, which suggests that prostanoids are involved in the up-regulated response. The protein synthesis inhibitor cycloheximide inhibited upregulation by approximately 50% in hypertrophic and control muscle strips from rat bladder and normal muscle from human bladder. Conclusions: These results demonstrate that bradykinin receptor responses are present in rat and human detrusor muscle and they can be up-regulated in vitro. Experiments on hypertrophic rat bladder revealed that this processis enhanced in hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 23:35:28