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Titolo:
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-watermultiple emulsion incorporating highly purified unsaturated fatty acid
Autore:
Kajita, M; Morishita, M; Takayama, K; Chiba, Y; Tokiwa, S; Nagai, T;
Indirizzi:
Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 aceut, Shinagawa Ku, Tokyo 1428501, Japan Nippon Suisan Kaisya Ltd, Cent Res Lab, Hachioji, Tokyo 1920906, Japan Nippon Suisan Kaisya Ltd Hachioji Tokyo Japan 1920906 okyo 1920906, Japan
Titolo Testata:
JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 10, volume: 89, anno: 2000,
pagine: 1243 - 1252
SICI:
0022-3549(200010)89:10<1243:EEBOVU>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; LINOLENIC ACID; ABSORPTION; PERMEABILITY; VESICLES; SODIUM; DRUGS; RATS;
Keywords:
vancomycin; docosahexaenoic acid; unsaturated fatty acid; emulsion; intestinal absorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Morishita, M Hoshi Univ, Dept Pharmaceut, Shinagawa Ku, Ebara 2-4-41, Tokyo 1428501, Japan Hoshi Univ Ebara 2-4-41 Tokyo Japan 1428501 o 1428501, Japan
Citazione:
M. Kajita et al., "Enhanced enteral bioavailability of vancomycin using water-in-oil-in-watermultiple emulsion incorporating highly purified unsaturated fatty acid", J PHARM SCI, 89(10), 2000, pp. 1243-1252

Abstract

The aim of this study was to evaluate the potential of an emulsion incorporating unsaturated fatty acids to improve the mucosal absorption of poorly absorbed drugs from rat intestinal loops in situ, using a water-in-oil-in-water (W/O/W) multiple emulsion. Vancomycin hydrochloride (VCM) was used as a model drug with low oral bioavailability. The entrapment efficiency of VCM in the emulsion was similar to 60% and remained constant over storage for1 month at 4 degrees C. The emulsion incorporating C18 unsaturated fatty acids or docosahexaenoic acid (DHA) markedly enhanced VCM absorption after colonic and rectal dosing. The effectiveness of DBA on VCM colonic absorption improvement was the same as that of oleic acid, and less than that of linoleic and linolenic acids. For rectal dosing, bioavailability was:similar among various emulsions,in the range 40-50%. The effect of the emulsion incorporating oleic acid or DHA on improving VCM enteral bioavailability was not increased proportional to the incorporated amount. The electrical resistance of membranes was not changed by the incorporation of various fatty acids in emulsions. Our results indicated that W/O/W emulsions incorporating C18 unsaturated fatty acid or DHA were useful carriers for improving the absorption of poorly absorbable drugs via the intestinal tract without gross changes to tight junction function. (C) 2000 Wiley-Liss, Inc. and the American Pharmaceutical Association.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:12:26