Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Successful dose-intensive treatment of desmoplastic small round cell tumorin three children
Autore:
Kurre, P; Felgenhauer, JL; Miser, JS; Patterson, K; Hawkins, DS;
Indirizzi:
Univ Washington, Childrens Hosp & Reg Med Ctr, Div Pediat Oncol, Dept Pediat, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 , Dept Pediat, Seattle, WA 98105 USA Univ Washington, Childrens Hosp & Reg Med Ctr, Dept Pathol, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 , Dept Pathol, Seattle, WA 98105 USA Beth Israel Deaconess Med Ctr, Spokane, WA USA Beth Israel Deaconess Med Ctr Spokane WA USA ss Med Ctr, Spokane, WA USA City Hope Natl Med Ctr, Duarte, CA 91010 USA City Hope Natl Med Ctr Duarte CA USA 91010 Med Ctr, Duarte, CA 91010 USA
Titolo Testata:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
fascicolo: 5, volume: 22, anno: 2000,
pagine: 446 - 450
SICI:
1077-4114(200009/10)22:5<446:SDTODS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGGRESSIVE MULTIMODALITY THERAPY; DIAGNOSIS; SPECTRUM;
Keywords:
desmoplastic small round cell tumor; translocation t(11;22) (p13;q11.2); PBSC support; radiation therapy; G-CSF; chemotherapy; dose intensification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kurre, P Univ Washington, Childrens Hosp & Reg Med Ctr, Div Pediat Oncol, Dept Pediat, Ch 29,4800 Sand Point Way NE, Seattle, WA 98105 USA Univ Washington Ch 29,4800 Sand Point Way NE Seattle WA USA 98105
Citazione:
P. Kurre et al., "Successful dose-intensive treatment of desmoplastic small round cell tumorin three children", J PED H ONC, 22(5), 2000, pp. 446-450

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare soft tissue tumor ofprimitive origin occurring primarily in children and young adults. Based on published reports in the literature, the response to conventional chemotherapy is poor. We report three pediatric patients successfully treated withdose-intensive, multimodal therapy. Between August 1994 and March 1998, weevaluated three consecutive patients with DSRCT at Children's Hospital andRegional Medical Center, Seattle, Washington. We established the diagnosisbased on clinical presentation, radiologic staging, and pathologic review with immunohistochemical staining. All patients received a combined modality protocol including dose-intensive chemotherapy (two of them with peripheral blood stem cell [PBSC] support), second look surgery, and consolidative local irradiation. The patients remain in continuous remission at 66, 42, and 26 months after diagnosis, respectively. Two of our patients were younger than any previously reported patient, extending the age group for which DSRCT should be considered on diagnosis of small round cell tumors. The uniform survival achieved in our series indicates potential benefit for the combination of dose-intensive multiagent chemotherapy, local irradiation, and aggressive surgical approach in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:01:54