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Titolo:
Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression
Autore:
West, DB; Blohm, FY; Truettt, AA; DeLany, JP;
Indirizzi:
Parke Davis, Mol Genet Lab, Alameda, CA 96501 USA Parke Davis Alameda CA USA 96501 is, Mol Genet Lab, Alameda, CA 96501 USA Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USALouisiana State Univ Baton Rouge LA USA 70808 , Baton Rouge, LA 70808 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 10, volume: 130, anno: 2000,
pagine: 2471 - 2477
SICI:
0022-3166(200010)130:10<2471:CLAPIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; MAMMARY-CANCER PREVENTION; BODY-COMPOSITION; SKELETAL-MUSCLE; DIETARY OBESITY; HUMANS; MOUSE; FAT; THERMOGENESIS; LIPOGENESIS;
Keywords:
mice; adipose tissue; metabolic rate; uncoupling protein; growth; obesity treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: West, DB Parke Davis, Mol Genet Lab, Alameda, CA 96501 USA Parke Davis Alameda CA USA 96501 enet Lab, Alameda, CA 96501 USA
Citazione:
D.B. West et al., "Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression", J NUTR, 130(10), 2000, pp. 2471-2477

Abstract

AKR/J mice fed a high fat diet were treated with a 1% (1 g/100 g) admixture of conjugated linoleic acids (CLA) for 5 wk and compared with control mice. Body weights, energy intakes and energy expenditure (EE) determined by indirect calorimetry were measured weekly. CLA treatment reduced adipose depot weights by similar to 50% but had no significant effects on either body weight or energy intake. CLA increased EE persistently by an average of 7.7% throughout the 5-wk experiment, This greater EE, despite no difference inenergy intake, was sufficient to account for the lower body fat stores in the CLA-treated mice. De novo fatty acid biosynthesis in adipose tissue, measured by incorporation of deuterium-labeled water, was not decreased by CLA treatment and therefore did not explain the lower adipose lipid in these mice. Expression of uncoupling protein (UCP) in skeletal muscle, white adipose tissue and kidney was not affected by CLA treatment. In brown adipose tissue, UCP1 expression was not affected by CLA treatment. However, UCP2 expression, although quite low, was significantly greater in CLA-fed mice. We conclude that CLA acts to reduce body fat stores by chronically increasing metabolic rate. This effect on metabolic rate is likely not due to increased UCP gene expression. Furthermore, the reduced body fat is not due to decreased de novo fatty acid synthesis in white adipose tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:47:20