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Titolo:
Enhanced spinal nociceptin receptor expression develops morphine toleranceand dependence
Autore:
Ueda, H; Inoue, M; Takeshima, H; Iwasawa, Y;
Indirizzi:
Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, Nagasaki8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 & Neurosci, Nagasaki8528521, Japan Univ Tokyo, Fac Med, Dept Pharmacol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Med, Dept Pharmacol, Tokyo 1130033, Japan Banyu Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan Banyu Tsukuba Res Inst Tsukuba Ibaraki Japan 3002611 araki 3002611, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 20, anno: 2000,
pagine: 7640 - 7647
SICI:
0270-6474(20001015)20:20<7640:ESNRED>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-S BINDING; MICE LACKING; ORPHANIN-FQ; ANALGESIA; NEUROPEPTIDE; POTENTIATION; INJECTIONS; AGONIST; BRAIN; CORD;
Keywords:
nociceptin/orphanin FQ; morphine; tolerance; dependence; plasticity; nonpeptidic antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, H Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan Nagasaki Univ 1-14 Bunkyo Machi Nagasaki Japan 8528521 521, Japan
Citazione:
H. Ueda et al., "Enhanced spinal nociceptin receptor expression develops morphine toleranceand dependence", J NEUROSC, 20(20), 2000, pp. 7640-7647

Abstract

The tolerance and dependence after chronic medication with morphine are thought to be representative models for studying the plasticity, including the remodeling of neuronal networks. To test the hypothesis that changes in neuronal plasticity observed in opioid tolerance or dependence are derived from increased activity of the anti-opioid nociceptin system, the effects ofchronic treatments with morphine were examined using nociceptin receptor knock-out (NOR-/-) mice and a novel nonpeptidic NOR antagonist, J-113397, which shows a specific and potent NOR antagonist activity in in vitro [S-35] GTP gamma S binding assay and in vivo peripheral nociception test. The NOR-/- mice showed marked resistance to morphine analgesic tolerance without affecting morphine analgesic potency in tail-pinch and tail-flick tests. The NOR-/- mice also showed marked attenuation of morphine-induced physical dependence, manifested as naloxone-precipitated withdrawal symptoms after repeated morphine treatments. Similar marked attenuation of morphine tolerance was also observed by single subcutaneous (10 mg/kg) or intrathecal (1 nmol)injection of J-113397, which had been given 60 min before the test in morphine-treated ddY mice. However, the intracerebroventricular injection (up to 3 nmol) did not affect the tolerance. On the other hand, morphine dependence was markedly attenuated by J-113397 that had been subcutaneously given 60 min before naloxone challenge. There was also observed a parallel enhancement of NOR gene expression only in the spinal cord during chronic morphine treatments. Together, these findings suggest that the spinal NOR system develops anti-opioid plasticity observed on morphine tolerance and dependence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 15:29:38