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Titolo:
The excitatory neuronal network of rat layer 4 barrel cortex
Autore:
Petersen, CCH; Sakmann, B;
Indirizzi:
Max Planck Inst Med Res, Dept Cell Physiol, D-69120 Heidelberg, Germany Max Planck Inst Med Res Heidelberg Germany D-69120 0 Heidelberg, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 20, anno: 2000,
pagine: 7579 - 7586
SICI:
0270-6474(20001015)20:20<7579:TENNOR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL NUCLEUS VPM; SOMATOSENSORY CORTEX; RECEPTIVE-FIELDS; SPATIOTEMPORAL CONVERGENCE; VIBRISSA; PLASTICITY; RESPONSES; POTENTIATION; NEOCORTEX; SYNAPSES;
Keywords:
neocortex; somatosensory cortex; barrel cortex; layer 4; synaptic transmission; EPSP; glutamate; neuronal network; dendritic morphology; axonal morphology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Petersen, CCH Max Planck Inst Med Res, Dept Cell Physiol, Jahnstr 29, D-69120 Heidelberg, Germany Max Planck Inst Med Res Jahnstr 29 Heidelberg Germany D-69120
Citazione:
C.C.H. Petersen e B. Sakmann, "The excitatory neuronal network of rat layer 4 barrel cortex", J NEUROSC, 20(20), 2000, pp. 7579-7586

Abstract

Sensory whiskers are mapped to rodent layer 4 somatosensory cortex as discrete units termed barrels, which can be visualized at high resolution in living brain slices. Both anatomical and physiological properties of the layer 4 neuronal network can thus be investigated in the context of the functional boundaries of this sensory map. Large-scale confinement of neuronal arbors to single barrels was suggested by restricted lateral diffusion of Dil across septa between barrels. Morphological analysis of dendritic and axonal arborizations of individual excitatory neurons showed that neuronal processes remain within the barrel of origin through polarization toward the center of the barrel. Functionally, the large-scale properties of the neuronalnetwork were investigated through mapping the spatial extent of field EPSPs, which were found to attenuate at barrel borders. This ensemble property of a layer 4 barrel was further investigated by analyzing the connectivity of pairs of excitatory neurons with respect to the locations of the somata. Approximately one-third of the excitatory neurons within the same barrel were synaptically coupled. At the septum between adjacent barrels the connectivity dropped rapidly, and very few connections were found between neuronslocated in adjacent barrels. Each layer 4 barrel is thus composed of an excitatory neuronal network, which to a first order approximation, acts independently of its neighbors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:43:37