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Titolo:
Leukemia inhibitory factor induces epidermal hyperplasia in patients with amyotrophic lateral sclerosis
Autore:
Hu, JG; Ono, S; Katayama, H; Imai, T; Shimizu, N; Nakagawa, H;
Indirizzi:
Teikyo Univ, Sch Med, Ichihara Hosp, Dept Neurol, Chiba 29901, Japan Teikyo Univ Chiba Japan 29901 hara Hosp, Dept Neurol, Chiba 29901, Japan Chiba Higashi Hosp, Dept Neurol, Natl Sanatorium, Chiba, Japan Chiba Higashi Hosp Chiba Japan pt Neurol, Natl Sanatorium, Chiba, Japan
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 3, volume: 115, anno: 2000,
pagine: 486 - 492
SICI:
0022-202X(200009)115:3<486:LIFIEH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL HUMAN KERATINOCYTES; SKELETAL-MUSCLE; SKIN; COLLAGEN; GROWTH; DIFFERENTIATION; ABNORMALITIES; INTERLEUKIN-6; CYTOKINE; RECEPTOR;
Keywords:
ALS; bedsore; epidermal hyperplasia; LIF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, S Teikyo Univ, Sch Med, Ichihara Hosp, Dept Neurol, 3426-3 Anesaki, Chiba 29901, Japan Teikyo Univ 3426-3 Anesaki Chiba Japan 29901 i, Chiba 29901, Japan
Citazione:
J.G. Hu et al., "Leukemia inhibitory factor induces epidermal hyperplasia in patients with amyotrophic lateral sclerosis", J INVES DER, 115(3), 2000, pp. 486-492

Abstract

We investigated the biochemical and morphologic alteration in skin of amyotrophic lateral sclerosis patients. We found an obvious high expression of leukemia inhibitory factor and distinct epidermal hyperplasia in the skin of amyotrophic lateral sclerosis patients compared with disease controls. The thickness and cell density, as well as the leukemia inhibitory factor immunostain density, of the epidermis in amyotrophic lateral sclerosis patients correlated positively with duration of illness. The striking fact was thesignificant epidermal hyperplasia correlating with leukemia inhibitory factor expression in amyotrophic lateral sclerosis patients (r = 0.94, p < 0.001). In vitro experiments revealed that leukemia inhibitory factor stimulated keratinocyte proliferation in primary keratinocyte culture and induced epidermal hyperplasia in skin organ culture. These findings lead to the hypothesis that a high expression of leukemia inhibitory factor is closely associated with epidermal hyperplasia in amyotrophic lateral sclerosis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:58:39