Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of 7 years of growth hormone replacement therapy in hypopituitary adults
Autore:
Chrisoulidou, A; Beshyah, SA; Rutherford, O; Spinks, TJ; Mayet, J; Kyd, P; Anyaoku, V; Haida, A; Ariff, B; Murphy, M; Thomas, E; Robinson, S; Foale, R; Johnston, DG;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sect Endocrinol & MEtab Med, Dept Clin Phys, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY ngland Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Dept Chem Pathol, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY ngland Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Dept Cardiol, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med LondonEngland W2 1NY ngland Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Div Biomed Sci, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY ngland Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0HS, England HammersmithHosp London England W12 0HS on Unit, London W12 0HS, England
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 10, volume: 85, anno: 2000,
pagine: 3762 - 3769
SICI:
0021-972X(200010)85:10<3762:EO7YOG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-DEFICIENT ADULTS; DENSITY-LIPOPROTEIN CHOLESTEROL; X-RAY ABSORPTIOMETRY; TOTAL-BODY POTASSIUM; INSULIN-SECRETION; DIASTOLIC FUNCTION; GLUCOSE; METABOLISM; MASS; ECHOCARDIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Chrisoulidou, A Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sect Endocrinol & MEtab Med, Dept Clin Phys, London W2 1NY, England Univ London Imperial Coll Sci Technol & Med London England W2 1NY
Citazione:
A. Chrisoulidou et al., "Effects of 7 years of growth hormone replacement therapy in hypopituitary adults", J CLIN END, 85(10), 2000, pp. 3762-3769

Abstract

Short-term studies of GH replacement in adult hypopituitarism have usuallydemonstrated beneficial effects on body composition and circulating lipids, with neutral or occasionally adverse effects on glucose tolerance. Pasting hyperinsulinemia has been reported. GH effects on cardiac function have been variable. The effects of long-term GH therapy, taking into account the consequences of increasing age, are not fully known. Thirty-three hypopituitary, initially middle-aged adults were studied over a 7-yr period; 12 patients took GH therapy (mean, 0.7 mg daily) continuously (group A); 11 took GH for only 6-18 months, a minimum of 5 yr previously (group B); and 10 patients never received GH therapy (group C). Other pituitary replacement was maintained. Effects on anthropometry, body composition (by bioimpedance analysis, total body potassium, and dual energy x-ray absorptiometry), circulating lipids, glucose and insulin concentrations, cardiac a-dimensional and Doppler echocardiography, and exercise tolerance were assessed before and after the treatment period. Continuous GH therapy had no significant effect on body weight, but it prevented the increase in waist circumference and waist to hip ratio that occurred in the patients without GH substitution (waist to hip ratio, group A, 0.87 +/- 0.08 at baseline, 0.85 +/- 9.09 at 7 yr; group B, 0.89 +/- 0.11 at baseline, 0.94 +/- 0.11 at 7 yr; P < 0.005 for GHeffect; group C, 0.87 +/- 0.10 at baseline, 0.92 +/- 0.10 at 7 yr; P < 0.005 for GH effect). A GH-induced decrease in subscapular skinfold thickness was also observed. By bioimpedance analysis, GH therapy caused an increase in total body water and fat-free mass, and a decrease in the percent body fat. Although changes occurred with time in all groups, no significant additional CII therapy effects were observed on glucose tolerance, insulin concentrations, lipid levels, cardiac dimensions, echocardiographic diastolic function, or exercise tolerance. In conclusion, prolonged GH substitution in middle-aged hypopituitary adults causes a sustained improvement in body composition. Other benefits, e.g. on lipid levels and exercise tolerance, werenot apparent at 7 yr when comparisons were made with GH-untreated hypopituitary controls. Potentially adverse effects on glucose tolerance and insulinemia did not develop with prolonged GN therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:35:33