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Titolo:
The A19G polymorphism in the 5 ' untranslated region of the human obese gene does not affect leptin levels in severely obese patients
Autore:
Lucantoni, R; Ponti, E; Berselli, ME; Savia, G; Minocci, A; Calo, G; De Medici, C; Liuzzi, A; Di Blasio, AM;
Indirizzi:
Ist Auxol Italiano, Mol Biol Lab, I-20135 Milan, Italy Ist Auxol ItalianoMilan Italy I-20135 ol Biol Lab, I-20135 Milan, Italy Osped San Giuseppe, Ist Auxol Italiano, Div Endocrinol & Metab Dis, I-28921 Verbania, Italy Osped San Giuseppe Verbania Italy I-28921 b Dis, I-28921 Verbania, Italy Osped San Giuseppe, Ist Auxol Italiano, Clin Chem Lab, I-28921 Verbania, Italy Osped San Giuseppe Verbania Italy I-28921 m Lab, I-28921 Verbania, Italy
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 10, volume: 85, anno: 2000,
pagine: 3589 - 3591
SICI:
0021-972X(200010)85:10<3589:TAPIT5>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM LEPTIN; OB GENE; GENDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Di Blasio, AM Ist Auxol Italiano, Mol Biol Lab, Va Monte Nero 32, I-20135 Milan, Italy Ist Auxol Italiano Va Monte Nero 32 Milan Italy I-20135 aly
Citazione:
R. Lucantoni et al., "The A19G polymorphism in the 5 ' untranslated region of the human obese gene does not affect leptin levels in severely obese patients", J CLIN END, 85(10), 2000, pp. 3589-3591

Abstract

Recently, the presence of different polymorphisms in the regulatory regionof the ob gene has been associated with variations in leptin levels. However, the results of these studies are still contradictory. The aim of the present investigation was to evaluate the presence of the A19G polymorphism in an Italian population of obese patients and to verify its association with leptin levels and anthropometric, metabolic, and clinical parameters. Twohundred five obese patients [body mass index (BMI) > 36 kg/m(2); 135 womenand 70 men; mean age, 46.9 +/- 14.23 yr] were screened for presence of thepolymorphism; 61 normal-weight controls (mean BMI, 21.05 kg/m(2); 53 women, 8 men) were also screened to compare polymorphism frequency. For obese patients, BMI, waist-to-hip ratio, resting energy expenditure, body composition, fasting leptin, total cholesterol, high-density lipoproteins, triglycerides, and caloric intake were determined. Genotype frequencies in obese andcontrol subjects were compared using the contingency table chi-square test; in obese subjects an ANOVA was performed to evaluate association between the polymorphism and several clinical parameters. No significant differences in genotype distribution between control and obese subjects were found. No significant correlations were found between this polymorphism and serum leptin levels and the other parameters considered. These findings confirm the results obtained in both a Finnish and a French population; taken together, these observations might rule out a significant role for the A19->G polymorphism in the regulation of leptin levels and other clinical, anthropometric, and metabolic parameters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:59:56