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Titolo:
Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice
Autore:
Fuller, PM; Warden, CH; Barry, SJ; Fuller, CA;
Indirizzi:
Univ Calif Davis, Sect Neurobiol Physiol & Behav, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 av, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis, Dept Pediat, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 at, Div Biol Sci, Davis, CA 95616 USA Univ Calif Davis, Rowe Program Genet, Sch Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 m Genet, Sch Med, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 89, anno: 2000,
pagine: 1491 - 1498
SICI:
8750-7587(200010)89:4<1491:EO2EOT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNCOUPLING PROTEIN-2; MESSENGER-RNA; EXPRESSION; TISSUE; HEPATOCYTES; SPACEFLIGHT; RESPONSES; TRANSPORT; OBESITY; LIPIDS;
Keywords:
uncoupling proteins; thermogenesis; lipids; hyperdynamic; energy expenditure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fuller, CA Univ Calif Davis, Sect Neurobiol Physiol & Behav, Div Biol Sci,1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CAUSA 95616 CA 95616 USA
Citazione:
P.M. Fuller et al., "Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice", J APP PHYSL, 89(4), 2000, pp. 1491-1498

Abstract

Altered ambient force environments affect energy expenditure via changes in thermoregulation, metabolism, and body composition. Uncoupling proteins (UCPs) have been implicated as potential enhancers of energy expenditure andmay participate in some of the adaptations to a hyperdynamic environment. To test this hypothesis, this study examined the homeostatic and circadian profiles of body temperature (T-b) and activity and adiposity in wild-type and UCP2/3 transgenic mice exposed to 1 and 2 G. There were no significant differences between the groups in the means, amplitudes, or phases of T-b and activity rhythms at either the 1- or 2-G level. Percent body fat was significantly lower in transgenic (5.2 +/- 0.2%) relative to the wild-type mice (6.2 +/- 0.1%) after 2-G exposure; mass-adjusted mesenteric and epididymal fat pads in transgenic mice were also significantly lower (P < 0.05). Thedata suggest that 1) the actions of two UCPs (UCP2 and UCP3) do not contribute to an altered energy balance at 2 G, although 2) UCP2 and UCP3 do contribute to the utilization of Lipids as a fuel substrate at 2 G.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:20:26