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Titolo:
Diaspirin cross-linked hemoglobin improves oxygen extraction capabilities in endotoxic shock
Autore:
Creteur, J; Zhang, HB; De Backer, D; Sun, QH; Vincent, JL;
Indirizzi:
Free Univ Brussels, Dept Intens Care, Erasme Univ Hosp, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 osp, B-1070 Brussels, Belgium
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 4, volume: 89, anno: 2000,
pagine: 1437 - 1444
SICI:
8750-7587(200010)89:4<1437:DCHIOE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELL DEFORMABILITY; STROMA-FREE HEMOGLOBIN; NITRIC-OXIDE; SYSTEMIC HEMODYNAMICS; REGIONAL CIRCULATION; BOVINE HEMOGLOBIN; O-2 DELIVERY; SEPSIS; RATS; HEMODILUTION;
Keywords:
sepsis; hypoxia; oxygen availability; dog experiment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Vincent, JL Free Univ Brussels, Dept Intens Care, Erasme Univ Hosp, 808 Route Lennik, B-1070 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1070 m
Citazione:
J. Creteur et al., "Diaspirin cross-linked hemoglobin improves oxygen extraction capabilities in endotoxic shock", J APP PHYSL, 89(4), 2000, pp. 1437-1444

Abstract

We studied the effects of diaspirin cross-linked hemoglobin (DCLHb), a cell-free hemoglobin derived from human erythrocytes, on blood flow distribution and tissue oxygen extraction capabilities in endotoxic shock. Eighteen pentobarbital sodium-anesthetized, mechanically ventilated dogs received 2 mg/kg off. coli endotoxin, followed by saline resuscitation to restore cardiac filling pressures to baseline levels. The animals were randomly divided into three groups: six served as control, six received DCLHb at a dose of 500 mg/kg (group I) and six DCLHb at a dose of 1,000 mg/kg (group 2). Cardiac tamponade was then induced by saline injection in the pericardial sac to progressively reduce cardiac index and thereby allow study of tissue oxygenextraction capabilities. DCLHb had a dose-dependent vasopressor effect butdid not significantly alter cardiac index or regional blood flow. During cardiac tamponade, critical oxygen delivery was 12.8 +/- 0.7 ml kg(-1) min(-1) in the control group, but 8.6 +/- 0.9 and 8.2 +/- 0.7 ml kg(-1) min(-1) in groups I and 2, respectively (both P < 0.05 vs. control group). The critical oxygen extraction ratio was 39.1 +/- 3.1% in the control group but 58.7 +/- 12.8% and 60.2 +/- 9.0% in groups I and 2, respectively. We conclude that DCLHb can improve whole body oxygen extraction capabilities during endotoxic shock in dogs.

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Documento generato il 09/07/20 alle ore 23:45:12