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Titolo:
Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: Radiation-induced lung toxicity
Autore:
Takigawa, N; Segawa, Y; Saeki, T; Kataoka, M; Ida, M; Kishino, D; Fujiwara, K; Ohsumi, S; Eguchi, K; Takashima, S;
Indirizzi:
Natl Shikoku Canc Ctr Hosp, Dept Internal Med, Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp Matsuyama Ehime Japan Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp, Dept Surg, Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp Matsuyama Ehime Japan Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp, Dept Radiol, Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp Matsuyama Ehime Japan Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp, Dept Clin Res, Matsuyama, Ehime, Japan Natl Shikoku Canc Ctr Hosp Matsuyama Ehime Japan Matsuyama, Ehime, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 3, volume: 48, anno: 2000,
pagine: 751 - 755
SICI:
0360-3016(20001001)48:3<751:BOOPSI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSERVATIVE SURGERY;
Keywords:
breast cancer; breast-conserving surgery; radiotherapy; bronchiolitis obliterans organizing pneumonia; bronchoalveolar lavage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takigawa, N Okayama Univ, Sch Med, Dept Med 2, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 2, Okayama 7008558, Japan
Citazione:
N. Takigawa et al., "Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: Radiation-induced lung toxicity", INT J RAD O, 48(3), 2000, pp. 751-755

Abstract

Purpose: Breast-conserving surgery and postoperative radiotherapy have played important roles in the treatment of early breast cancer. Bronchiolitis obliterans organizing pneumonia (BOOP) syndrome has recently been reported to be one of the complications of adjuvant radiotherapy. The purpose of this study was to determine the incidence of and risk factors for BOOP syndrome in breast cancer patients. Methods and Materials: Between January 1996 and December 1998, 157 patients with breast cancer underwent radiotherapy after breast-conserving surgery. The criteria used for the diagnosis of POOP syndrome were as follows: 1) radiation therapy to the breast within 12 months, 2) general and/or respiratory symptoms lasting for at least 2 weeks, 3) radiographic lung infiltrates outside the radiation port, and 4) no evidence of a specific cause. Results: BOOP syndrome developed in 4 (2.5%) patients, who had fever and nonproductive cough, with patchy infiltrative shadows on chest roentgenograms which emerged between 5 and 6 months after radiotherapy. The symptoms andpulmonary infiltrates were rapidly improved by treatment with prednisone (40 mg/day), which was tapered over 2- to 5-month periods. However, BOOP syndrome relapsed in all cases during the tapering period or after withdrawal of prednisone. The eosinophil and neutrophil counts were increased and the ratios of CD4+ to CD8+ lymphocytes were elevated in bronchoalveolar lavage fluid in all four cases. There were no differences in proportions of patients by age, irradiated breast site, use of tamoxifen and/or chemotherapy, orradiation dose between those with and without BOOP syndrome. Conclusions: BOOP syndrome is considered an intractable form of lung toxicity after radiotherapy to the breast. An immunologic reaction mediated by eosinophils, neutrophils, and lymphocytes may be responsible for the development of this syndrome. Methods of prevention of POOP syndrome should be established. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:15:56