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Titolo:
Gold microspheres: a selective technique for producing biologically effective dose enhancement
Autore:
Herold, DM; Das, IJ; Stobbe, CC; Iyer, RV; Chapman, JD;
Indirizzi:
Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 10, volume: 76, anno: 2000,
pagine: 1357 - 1364
SICI:
0955-3002(200010)76:10<1357:GMASTF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOMIC-NUMBER INTERFACES; TISSUE-TITANIUM INTERFACES; MEGAVOLTAGE PHOTON BEAMS; BACKSCATTER RADIATION; DOSIMETRY; PERTURBATION; TUMORS; SURVIVAL; AGENTS; IODINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Das, IJ Univ Penn, Dept Radiat Oncol, 3400 Spruce St,2 Donner Bldg, Philadelphia, PA 19104 USA Univ Penn 3400 Spruce St,2 Donner Bldg Philadelphia PAUSA 19104 A
Citazione:
D.M. Herold et al., "Gold microspheres: a selective technique for producing biologically effective dose enhancement", INT J RAD B, 76(10), 2000, pp. 1357-1364

Abstract

Purpose: To investigate dose enhancement and radiosensitization associatedwith electrons produced and scattered from gold particles suspended in cells in vitro and with tumour cells growing in vivo irradiated with low-energy photons. Materials and methods: CHO-KI, EMT-6 and DU-145 cells were irradiated withkilovoltage X-ray and Cs-137 beams in slowly stirred suspensions in the presence of various concentrations of gold particles (1.5-3.0 mu m); cell survival was measured by clonogenic assay. Gold particles were injected directly into EMT-6 tumours growing in scid mice prior to their irradiation. Tumour cell killing was assayed by an in vivo-in vitro technique. Results: Dose enhancement was confirmed by both Fricke dosimetry and cell killing for 100, 140, 200 and 240 kVp X-rays, but not for Cs-137 gamma-rays. For the chemical dosimeter, a dose enhancement (DMF) of 1.42 was measuredfor 1% gold particle solutions irradiated with 200 kVp X-rays. When rodentand human cells were irradiated in the presence of 1% gold particles, DMF values at the 10% survival level ranged from 1.36 to 1.54, with an overall average value of 1.43. Preliminary attempts to deliver these gold particlesto tumour cells in vivo by intra-tumour injection resulted in modest radiosensitization but extremely heterogeneous distribution. Conclusions: An increased biologically effective dose can be produced by gold microspheres suspended in cell culture or distributed in tumour tissue exposed to kilovoltage photon beams. With the increasing use of interstitial brachytherapy with isotopes that produce low-energy photons, high-Z particles might find a role for significantly improving the therapeutic ratio.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:04:20