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Titolo:
Expression of cell cycle regulator genes in KB, a human squamous cell carcinoma cell line, after irradiation
Autore:
Uno, M; Otsuki, T; Hiratsuka, J; Yoden, E; Aihara, T; Harada, T; Imajo, Y;
Indirizzi:
Kawasaki Med Sch, Dept Radiat Oncol, Okayama 7010192, Japan Kawasaki Med Sch Okayama Japan 7010192 iat Oncol, Okayama 7010192, Japan Kawasaki Med Sch, Dept Hyg, Okayama 7010192, Japan Kawasaki Med Sch Okayama Japan 7010192 Dept Hyg, Okayama 7010192, Japan Kawasaki Med Sch, Dept Otorhinolaryngol, Okayama 7010192, Japan Kawasaki Med Sch Okayama Japan 7010192 olaryngol, Okayama 7010192, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 17, anno: 2000,
pagine: 947 - 954
SICI:
1019-6439(200011)17:5<947:EOCCRG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53-MEDIATED G(1) ARREST; IONIZING-RADIATION; INDUCED APOPTOSIS; CDK INHIBITOR; TUMOR CELLS; DNA-DAMAGE; P53; P21; ACTIVATION; PATHWAY;
Keywords:
irradiation; cell cycle regulator; gene expression; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Uno, M Kawasaki Med Sch, Dept Radiat Oncol, 577 Matsushima, Okayama 7010192, Japan Kawasaki Med Sch 577 Matsushima Okayama Japan 7010192 10192, Japan
Citazione:
M. Uno et al., "Expression of cell cycle regulator genes in KB, a human squamous cell carcinoma cell line, after irradiation", INT J ONCOL, 17(5), 2000, pp. 947-954

Abstract

DNA damage induced by irradiation causes overexpression of the p53 gene, and subsequently the upregulation of p53 downstream genes involved in cell cycle modification. Irradiated malignant cells which possess wild-type p53 have been known to undergo G(1) arrest due to p21/Cip1/Waf1 upregulation. Other p53 downstream genes related to the modification of the cell cycle suchas gadd45 may cause G(2) arrest. Many of the genes which regulate the cellcycle progression have been identified, including the G(1) phase specific ink4 family of cyclin-dependent kinase inhibitors (CDK-I), another group ofCDK-Is, which affect the cyclin-CDK complexes ubiquitously, and S/G(2) accelerator genes. The sequential changes in these cell cycle regulator genes after irradiation has not been clarified. We analyzed the appearance of theapoptotic fraction and cell cycle perturbation after irradiation using KB,a human squamous cell carcinoma line derived from oral floor, and examinedthe alteration of gene expression for cell cycle regulator genes. The KB cells proceeded to undergo apoptosis in a time and dose dependent manner after irradiation and showed G(2) arrest accompanied by upregulation of p53, ubiquitous CDK-Is, and S and G(2) accelerator genes.

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Documento generato il 29/03/20 alle ore 01:23:35