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Titolo:
Blood supply, oxygenation status and metabolic micromilieu of breast cancers: Characterization and therapeutic relevance (Review)
Autore:
Vaupel, P; Hockel, M;
Indirizzi:
Univ Mainz, Inst Physiol & Pathophysiol, D-55099 Mainz, Germany Univ Mainz Mainz Germany D-55099 & Pathophysiol, D-55099 Mainz, Germany Univ Leipzig, Dept Obstet & Gynecol, Leipzig, Germany Univ Leipzig Leipzig Germany g, Dept Obstet & Gynecol, Leipzig, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 5, volume: 17, anno: 2000,
pagine: 869 - 879
SICI:
1019-6439(200011)17:5<869:BSOSAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; RECURRENCE-FREE SURVIVAL; MURINE TUMOR-CELLS; INDEPENDENT PROGNOSTIC INDICATOR; MICROVESSEL QUANTITATION; MICROENVIRONMENTAL FACTORS; GLUCOSE STARVATION; TISSUE OXYGENATION; VESSEL INVASION; SOLID TUMORS;
Keywords:
bioenergetic status; blood flow; breast cancer; fibrocystic mastopathy; microcirculation; microenvironment; oxygenation status; respiration rate; tumor pH; vascularization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Vaupel, P Univ Mainz, Inst Physiol & Pathophysiol, Duesbergweg 6, D-55099 Mainz, Germany Univ Mainz Duesbergweg 6 Mainz Germany D-55099 9 Mainz, Germany
Citazione:
P. Vaupel e M. Hockel, "Blood supply, oxygenation status and metabolic micromilieu of breast cancers: Characterization and therapeutic relevance (Review)", INT J ONCOL, 17(5), 2000, pp. 869-879

Abstract

The metabolic microenvironment of a tumor is predominantly determined by the efficacy of blood flow, flux parameters (such as diffusion and convective currents in the interstitial space) and metabolic rates. The most important factors in this context include oxygen and nutrient supply, tissue pH and the bioenergetic status. It is now widely accepted that the metabolic microenvironment of a tumor can dramatically influence a range of factors suchas proliferation rate, cell cycle position, growth rate and the development of apoptosis and necrosis. At the same time, these parameters can have animpact on tumor detection, therapeutic response to conventional irradiation, some chemotherapy agents and other non-surgical treatment modalities, while also having the capacity to modulate malignant progression (e.g., enhanced local spread, metastasis). The metabolic microenvironment appears to have a potentially important role to play in the prediction of long-term treatment outcome, and thus might be useful as a prognostic factor. Currently available information related to the parameters defining the metabolic microenvironment in breast cancers are presented in this review. According to these data, significant variations in these relevant factors are likely to occur between different locations within a tumor, and between tumors of the same clinical size, stage, grade and histology. The 'physiological barriers'to treatment are also considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:10:24