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Titolo:
Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit
Autore:
Tarcan, T; Siroky, MB; Park, K; Goldstein, I; Azadzoi, KM;
Indirizzi:
Boston VA Med Ctr, Dept Urol Res, Boston, MA 02130 USA Boston VA Med Ctr Boston MA USA 02130 Dept Urol Res, Boston, MA 02130 USA Boston Univ, Sch Med, Dept Urol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Sch Med, Dept Urol, Boston, MA 02118 USA Chonnam Natl Univ, Sch Med, Dept Urol, Kwangju, South Korea Chonnam Natl Univ Kwangju South Korea , Dept Urol, Kwangju, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 4, volume: 12, anno: 2000,
pagine: 235 - 240
SICI:
0955-9930(200008)12:4<235:SAOAIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PENILE ERECTION; PARAVENTRICULAR NUCLEUS; RATS; OXYTOCIN; TUMESCENCE; MODEL; DOMPERIDONE; IMPOTENCE; MEN;
Keywords:
apomorphine; clitoris; vagina; engorgement; blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Azadzoi, KM Boston VA Med Ctr, Dept Urol Res, 150 S Huntington Ave, Boston, MA 02130 USA Boston VA Med Ctr 150 S Huntington Ave Boston MA USA 02130 USA
Citazione:
T. Tarcan et al., "Systemic administration of apomorphine improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit", INT J IMPOT, 12(4), 2000, pp. 235-240

Abstract

Clitoral and vaginal engorgement during sexual stimulation depend in part on the increase of arterial inflow. It has been shown that apomorphine (APO), a non-selective dopamine receptor agonist, produces penile erection by activating dopaminergic receptors in the central nervous system. Our aim wasto study whether systemic administration of APO improves the hemodynamic mechanism of clitoral and vaginal engorgement in the rabbit. Female New Zealand white rabbits (3.5-4 kg, n = 6) were anesthetized. To examine sexual arousal function, the vaginal/clitoral branch of the pelvic nerve was stimulated electrically and maximal increases in clitoral intracavernosal and vaginal wall blood flows and pressures were recorded. After this APO was injected intravenously in a dose-response manner (0.05, 0.1, 0.2,0.3 and 0.4 mg/kg) and nerve stimulation was performed after each dose. Changes In nerve-stimulated increase of clitoral intracavernosal and vaginal blood flows and pressures after APO was compared to those recorded before APO. Electrical stimulation of the vaginal/clitoral branch of the pelvic nerve significantly increased clitoral intracavernosal and vaginal wall blood flows in the rabbit. Intravenous administration of APO caused concentration dependent increase in nerve stimulation-induced peak clitoral intracavernosaland vaginal wall blood flows reaching to statistically significant at the concentration of 0.1 and 0.2 mg/kg. Intravenous administration of APO greater than 0.2 mg/kg (0.3 and 0.4 mg/kg) were less effective or produced adverse effects on clitoral intracavernosal and vaginal wall blood flows. Intravenous APO also tended to increase nerve-stimulated increase of clitoral intracavernosal and vaginal wall pressures, but the effect was not statistically significant. In conclusion, our studies suggest that systemic administration of APO mayimprove clitoral and vaginal engorgement by increasing clitoral intracavernosal and vaginal wall arterial inflow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:43:57