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Titolo:
Endogenous digitalislike factors in obstructive sleep apnea
Autore:
Paci, A; Marrone, O; Lenzi, S; Prontera, C; Nicolini, G; Ciabatti, G; Ghione, S; Bonsignore, G;
Indirizzi:
CNR, Inst Clin Physiol, I-56100 Pisa, Italy CNR Pisa Italy I-56100CNR, Inst Clin Physiol, I-56100 Pisa, Italy CNR, Inst Resp Pathophysiol, Palermo, Italy CNR Palermo ItalyCNR, Inst Resp Pathophysiol, Palermo, Italy Univ Pisa, Dept Internal Med, Pisa, Italy Univ Pisa Pisa ItalyUniv Pisa, Dept Internal Med, Pisa, Italy
Titolo Testata:
Hypertension research
, volume: 23, anno: 2000, supplemento:, S
pagine: S87 - S91
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE FACTOR; PUMP INHIBITORS; HUMAN PLASMA; OUABAIN; DIGOXIN; ATPASE; MARINOBUFAGENIN; SUBSTANCE; COMPOUND;
Keywords:
endogenous digitalislike factors; obstructive sleep apnea; radioreceptor assay; hypoxia; ouabain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Paci, A CNR, Inst Clin Physiol, Via Savi 8, I-56100 Pisa, Italy CNR Via Savi 8 Pisa Italy I-56100 Via Savi 8, I-56100 Pisa, Italy
Citazione:
A. Paci et al., "Endogenous digitalislike factors in obstructive sleep apnea", HYPERTENS R, 23, 2000, pp. S87-S91

Abstract

Recent studies have provided evidence that hypoxia may stimulate the release of endogenous digitalislike factors (EDLF), Obstructive sleep apnea(OSA)is characterized by intermittent hypoxia during sleep and may be associated with sympathetic activation and a high risk of developing hypertension, This study was designed to measure EDLF in the plasma of patients with OSA diagnosed by polysomnography, with patients being classified by the number of apneic-hypopneic episodes/h sleep (apnea-hypopnea index, AHI), Plasma wasobtained in the morning from 8 male normotensive OSA patients (OSA-N) (AHI70 +/- 6), 2 untreated hypertensive OSA patients (OSA-HT), and 11 age-matched healthy male controls (C). EDLFs of different hydrophobicities were separated from the same plasma sample by solid-state C18-cartridges with 25% acetonitrile (ACN) (EDLF-1) followed by 40% ACN (EDLF-2). This procedure recovered ouabain in the first fraction and digoxin and digoxigenin in the second. EDLF was quantified in pM ouabain-equivalents by a human placenta radioreceptor assay, EDLF-1 levels were similar for OSA-N and C (231 +/- 55 vs.258 +/- 58), whereas EDLF-2 levels were increased in OSA-N (244 +/- 51 vs.110 +/- 25 in C, p = 0,02), Norepinephrine was increased in apneics, The two OSA-HT had EDLF and norepinephrine levels similar to OSA-N, These preliminary results suggest that OSA is associated with an increase in the more hydrophobic EDLF levels in both normotensive and hypertensive states. No significant increase was found for the less hydrophobic ouabain-like EDLF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:24:02