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Titolo:
Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules
Autore:
Sugawara-Yokoo, M; Urakami, Y; Koyama, H; Fujikura, K; Masuda, S; Saito, H; Naruse, T; Inui, K; Takata, K;
Indirizzi:
Gunma Univ, Inst Mol & Cellular Regulat, Dept Cell Biol, Lab Mol & Cellular Morphol, Gunma 3718512, Japan Gunma Univ Gunma Japan 3718512 & Cellular Morphol, Gunma 3718512, Japan Gunma Univ, Sch Med, Dept Internal Med 3, Gunma 3718511, Japan Gunma UnivGunma Japan 3718511 Dept Internal Med 3, Gunma 3718511, Japan Kyoto Univ Hosp, Fac Med, Dept Pharm, Sakyo Ku, Kyoto 6068507, Japan KyotoUniv Hosp Kyoto Japan 6068507 harm, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 3, volume: 114, anno: 2000,
pagine: 175 - 180
SICI:
0948-6143(200009)114:3<175:DLOOCT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL-CHARACTERIZATION; EXPRESSION; CLONING; OCT2; MECHANISMS; SECRETION;
Keywords:
organic cation transporter; rOCT1; rOCT2; kidney; proximal tubule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takata, K Gunma Univ, Inst Mol & Cellular Regulat, Dept Cell Biol, Lab Mol& Cellular Morphol, Gunma 3718512, Japan Gunma Univ Gunma Japan 3718512 r Morphol, Gunma 3718512, Japan
Citazione:
M. Sugawara-Yokoo et al., "Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules", HISTOCHEM C, 114(3), 2000, pp. 175-180

Abstract

Organic cation transporters play an important role in the secretion of cationic drugs as well as endogenous cationic metabolites in the renal tubules. Immunoblotting showed the presence of organic cation transporter proteins, rOCT1 and rOCT2, in the rat kidney. By immunofluorescence microscopy, rOCT1 was shown to be concentrated in the proximal tubules in the renal cortex. rOCT2, on the other hand, was rich in the proximal tubules in the outer stripe of the outer medulla. Confocal microscopy revealed that both rOCT1 and rOCT2 were localized to the basolateral membranes of these tubule cells. These findings directly show that rOCT1 and rOCT2 are basolateral membrane proteins and are differentially distributed along the proximal tubules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 16:01:34