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Titolo:
THE SYNTHESIS AND RADIOLABELING OF NOVEL MARKERS OF TISSUE HYPOXIA OFTHE IODINATED AZOMYCIN NUCLEOSIDE CLASS
Autore:
SCHNEIDER RF; ENGELHARDT EL; STOBBE CC; FENNING MC; CHAPMAN JD;
Indirizzi:
FOX CHASE CANC CTR,DEPT RADIAT ONCOL,TUMOR BIOL & BIOPHYS SECT,7701 BURHOLME AVE PHILADELPHIA PA 19111
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 7, volume: 39, anno: 1997,
pagine: 541 - 557
SICI:
0362-4803(1997)39:7<541:TSARON>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IODOAZOMYCIN ARABINOSIDE; THERAPY; CANCER;
Keywords:
HYPOXIC MARKERS; TUMOR OXYGENATION; AZOMYCIN NUCLEOSIDES; TUMOR RADIORESISTANCE; BIOREDUCIBLE DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Schneider et al., "THE SYNTHESIS AND RADIOLABELING OF NOVEL MARKERS OF TISSUE HYPOXIA OFTHE IODINATED AZOMYCIN NUCLEOSIDE CLASS", Journal of labelled compounds & radiopharmaceuticals, 39(7), 1997, pp. 541-557

Abstract

Seven second-generation hypoxic markers of the iodinated azomycin nucleoside class have been synthesized and tested for hypoxia marking activity with tumor cells in vitro and in vivo. beta-D-lodoazomycin galactoside (IAZG) and beta-D-iodoazomycin xylopyranoside (IAZXP) demonstrated superior hypoxia marking properties relative to IAZA because of their higher water solubilities, rapid plasma clearance rates from tumor-bearing mice and maximum tumor/blood (T/B) and tumor/muscle (T/M) ratios. Our studies with animal tumor models show that T/B or T/M ratios of these markers determined by scintigraphy or planar imaging can predict for the relative degree of tumor hypoxia and for tumor radioresistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:37:28