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Titolo:
Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum
Autore:
Turvill, JL; Connor, P; Farthing, MJG;
Indirizzi:
St Bartholomews & Royal London Sch Med & Dent, Digest Dis Res Ctr, London E1 2AD, England St Bartholomews & Royal London Sch Med & Dent London England E1 2AD land
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 4, volume: 119, anno: 2000,
pagine: 1037 - 1044
SICI:
0016-5085(200010)119:4<1037:N1A2RM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; ORAL REHYDRATION SOLUTION; HEAT-LABILE ENTEROTOXIN; INDUCED FLUID SECRETION; ESCHERICHIA-COLI; SUBSTANCE-P; ELECTROLYTE TRANSPORT; TACHYKININ RECEPTORS; DIARRHEAL DISEASE; SENSORY NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Turvill, JL St Bartholomews & Royal London Sch Med & Dent, Digest Dis Res Ctr, Turner St, London E1 2AD, England St Bartholomews & Royal London Sch Med & Dent Turner St London England E1 2AD
Citazione:
J.L. Turvill et al., "Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum", GASTROENTY, 119(4), 2000, pp. 1037-1044

Abstract

Background & Aims: Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic waterand electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neurokinin receptor antagonists on cholera toxin-, Escherichia coil heat-labile enterotoxin (LT)-, and heat-stable enterotoxin (STa)-induced water secretion in an in vivo rat jejunal perfusion model. Methods: Anesthetized adult male Wistar rats were pretreated with substance P antagonists (D-Pro(2), D-Trp(7,9), substance P, 0.1-3.0 mg/kg; or CP 96,345/4, 0.3-3 mg/kg) or neurokinin (NH)-1 (sendide, 1.0 mg/kg), NK-2 (GR83074, 1.0 mg/kg), or NK-3 ([Trp(7),beta Ala(8)]NKA(4-10), 1.0 mg/kg) receptor antagonists. In a subgroup, extrinsic sensory afferents were ablated by pretreatment with capsaicin, Jejunal perfusion, with a plasma electrolyte solution containing a nonabsorbable marker, was undertaken after exposure to cholera toxin (25 mu g), LT (25 mu g), STa (200 mu g/L), or saline. Results: Choleratoxin-induced water and electrolyte secretion was inhibited by the substance P antagonists and the NK-1 and NK-2 receptor antagonists, but not by theNK-3 receptor antagonist or by pretreatment with capsaicin. Neither LT- nor STa-induced secretions were affected by the pretreatments, Conclusions: Prosecretory pathways involving NK-1 and NK-2 receptors specifically mediatethe actions of cholera toxin in the small intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:15:27