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Titolo:
Comparison of Heparin and Steroids in the Treatment of moderate and severeulcerative colitis
Autore:
Panes, J; Esteve, M; Cabre, E; Hinojosa, J; Andreu, M; Sans, M; Fernandez-Banares, F; Feu, F; Gassull, MA; Pique, JM;
Indirizzi:
Inst Invest Biomed August Pi & Sunyer, Inst Clin Malalties Digest, Dept Gastroenterol, Barcelona, Spain Inst Invest Biomed August Pi & Sunyer Barcelona Spain Barcelona, Spain Hosp Mutua, Serv Aparell Digestiu, Terrassa, Spain Hosp Mutua Terrassa Spain Mutua, Serv Aparell Digestiu, Terrassa, Spain Hosp Germans Trias & Pujol, Serv Aparell Digestiu, Badalona, Spain Hosp Germans Trias & Pujol Badalona Spain ell Digestiu, Badalona, Spain Hosp Sagunto, Med Interna Serv, Valencia, Spain Hosp Sagunto Valencia Spain Sagunto, Med Interna Serv, Valencia, Spain Hosp del Mar, Serv Aparell Digestiu, Barcelona, Spain Hosp del Mar Barcelona Spain r, Serv Aparell Digestiu, Barcelona, Spain
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 4, volume: 119, anno: 2000,
pagine: 903 - 908
SICI:
0016-5085(200010)119:4<903:COHASI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY-BOWEL-DISEASE; UNFRACTIONED HEPARIN; THERAPY; CYCLOSPORINE; MUTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Panes, J Hosp Clin Barcelona, Dept Gastroenterol, Villarroel 170, E-08036 Barcelona, Spain Hosp Clin Barcelona Villarroel 170 Barcelona Spain E-08036 Spain
Citazione:
J. Panes et al., "Comparison of Heparin and Steroids in the Treatment of moderate and severeulcerative colitis", GASTROENTY, 119(4), 2000, pp. 903-908

Abstract

Background & Aims: Unfractionated heparin has been found to reduce symptoms and improve healing as adjuvant therapy in patients with ulcerative colitis, The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone, Methods: A multicenter randomized trial with blinded endpoint evaluation was conducted in patients hospitalized for moderate or severe ulcerative colitis, Patients were randomized to receive heparin as a continuous infusion or methylprednisolone (0.75-1 mg.kg(-1).day(-1)), Results: Twenty-five patients entered the study: 13 received methylprednisolone and 12 received heparin, By day 10, 69% of patients in the methylprednisolone group, but none in the heparin group, achieved significant improvement or remission, C-reactive protein levels significantly decreased in the methylprednisolone group but not in the heparin group, Three patients in the heparin group were withdrawn before day 10 because of an adverse event: rectal bleeding needing transfusion (2 cases) or surgery (1 case). The proportion of patients with persistent rectal bleeding at day 10 was 31% in the methylprednisolone group and 90% in the heparin group (P < 0.05), Conclusions: Unfractionated heparin as monotherapy is not effective in the treatment of moderate or severe ulcerative colitis and is associated with significant bleeding complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:23:36