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Titolo:
Management of women with polycystic ovary syndrome who experienced premature luteinization during clomiphene citrate treatment
Autore:
Lidor, AL; Goldenberg, M; Cohen, SB; Seidman, DS; Mashiach, S; Rabinovici, J;
Indirizzi:
Chaim Sheba Med Ctr, Dept Obstet & Gynecol, Reprod Med & Infertil Clin, IL-52621 Ramat Gan, Israel Chaim Sheba Med Ctr Ramat Gan Israel IL-52621 IL-52621 Ramat Gan, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 4, volume: 74, anno: 2000,
pagine: 749 - 752
SICI:
0015-0282(200010)74:4<749:MOWWPO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; HUMAN MENOPAUSAL GONADOTROPIN; FOLLICLE-STIMULATING-HORMONE; INVITRO FERTILIZATION; OVULATION INDUCTION; CLINICAL-APPLICATIONS; LEUPROLIDE ACETATE; EMBRYO TRANSFER; AGONIST; COMBINATION;
Keywords:
premature luteinization; polycystic ovary syndrome; gonadotropin-releasing hormone agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lidor, AL Chaim Sheba Med Ctr, Dept Obstet & Gynecol, Reprod Med & Infertil Clin, IL-52621 Ramat Gan, Israel Chaim Sheba Med Ctr Ramat Gan Israel IL-52621 amat Gan, Israel
Citazione:
A.L. Lidor et al., "Management of women with polycystic ovary syndrome who experienced premature luteinization during clomiphene citrate treatment", FERT STERIL, 74(4), 2000, pp. 749-752

Abstract

Objective: To determine the preferred treatment modality in patients with PCOS who experienced premature luteinization during CC treatment. Design: Prospective randomized study. Setting: Tertiary medical center. Patients: Twenty-two infertile women with PCOS demonstrating premature luteinization during at least two consecutive CC cycles. Interventions: Randomized induction of ovulation either with FSH alone or with GnRH agonist combined with FSH for a single treatment cycle. Main Outcome Measures: Premature luteinization was defined as serum progesterone >1.5 ng/mL before hCG administration. Results: Premature luteinization occurred in eight of the 10 patients (80%) in group A and in two of the 12 patients in group B (16.6%). This result corresponds to the higher mean (+/-SD) progesterone level present in group A patients as compared to those in group B (2.0 +/- 1.2 ng/mL vs. 1.2 +/- 0.6 ng/mL, P=0.03). No pregnancies were achieved in group A, whereas the pregnancy rate per cycle observed in group B was 33.3% (4/12). On the day of hCG administration, the maximum mean (+/-SD) estradiol level was significantly lower (P<0.0001) in group A (210.6 +/- 37.9 pg/mL) than in group B (600.3 +/- 253.8 pg/mL). The treatment duration and the number of FSH ampules used did not differ between the groups. Conclusions: Pituitary desensitization with GnRH analog in combination with FSH is superior to FSH-only treatment in PCOS patients who demonstrate premature luteinization during CC treatment. (Fertil Steril (R) 2000;74:749-52. (C) 2000 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:46:40