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Titolo:
Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis
Autore:
Peng, Y; Kok, KH; Xu, RH; Kwok, KHH; Tay, D; Fung, PCW; Kung, HF; Lin, MCM;
Indirizzi:
Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China First Mil Med Univ China, Dept Neurol, Guangzhou, Peoples R China First Mil Med Univ China Guangzhou Peoples R China hou, Peoples R China Univ Hong Kong, Dept Med, Div Med Phys, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China WiCell Res Inst, Madison, WI USA WiCell Res Inst Madison WI USAWiCell Res Inst, Madison, WI USA Univ Hong Kong, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ HongKong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 482, anno: 2000,
pagine: 37 - 43
SICI:
0014-5793(20000929)482:1-2<37:MCIRBP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; TRANSLATIONAL REGULATION; RETINOIC ACID; GENE XLIM-1; EXPRESSION; PRONEPHROS; INDUCTION; CIRP; ECTODERM; TUBULES;
Keywords:
cold inducible RNA binding protein; cDNA cloning; pronephros; morphogenetic movement; Xenopus laevis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, MCM Univ Hong Kong, Inst Mol Biol, 8-F Kadoorie Biol Sci Bldg,Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong 8-F Kadoorie Biol Sci Bldg,Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
Y. Peng et al., "Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis", FEBS LETTER, 482(1-2), 2000, pp. 37-43

Abstract

We cloned a major isoform of Xenopus homologue of cold inducible RNA binding protein (CIRP), XCIRP-1. XCIRP-1 was neither cold inducible nor essential for cell division during early embryonic development, Suppression of XCIRP-1 dose dependently produced tailbuds with deformations of the brain and internal organs. The defects were XCIRP-1 specific as they could be rescued by sense transcript. Suppression of XCIRP-1 also disrupted the morphogenetic migration of the C3 blastomeres (lineaged to become the embryonic kidney,the pronephros), In animal cap explants, depletion of XCIRP-1 inhibited activin/retinoic acid induced expressions of pronephros related Xlim-1 and WT1 genes. These results suggest that XCIRP-1 is required for the specification and morphogenetic lineage migration of the pronephros, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:36:49