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Titolo:
Low leptin mRNA level in adipose tissue and normoleptinemia in experimental chronic renal failure
Autore:
Swierczynski, J; Korczynska, J; Szolkiewicz, M; Karbowska, J; Kochan, Z; Nieweglowski, T; Kusiak, E; Rutkowski, B;
Indirizzi:
Med Univ Gdansk, Dept Nephrol, PL-80211 Gdansk, Poland Med Univ Gdansk Gdansk Poland PL-80211 Nephrol, PL-80211 Gdansk, Poland Med Univ Gdansk, Dept Biochem, PL-80211 Gdansk, Poland Med Univ Gdansk Gdansk Poland PL-80211 Biochem, PL-80211 Gdansk, Poland Med Univ Gdansk, Dept Endocrinol, PL-80211 Gdansk, Poland Med Univ GdanskGdansk Poland PL-80211 docrinol, PL-80211 Gdansk, Poland
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 1, volume: 9, anno: 2001,
pagine: 54 - 59
SICI:
1018-7782(2001)9:1<54:LLMLIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-EXPRESSION; BODY-FAT CONTENT; PLASMA LEPTIN; HYPERLEPTINEMIA; CLOFIBRATE; INCREASE; DISEASE; KIDNEY; ENZYME;
Keywords:
ob gene expression; leptin mRNA; leptin; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rutkowski, B Med Univ Gdansk, Dept Nephrol, Debinki 7A, PL-80211 Gdansk, Poland Med Univ Gdansk Debinki 7A Gdansk Poland PL-80211 sk, Poland
Citazione:
J. Swierczynski et al., "Low leptin mRNA level in adipose tissue and normoleptinemia in experimental chronic renal failure", EXP NEPHROL, 9(1), 2001, pp. 54-59

Abstract

Background: Anorexia and weight loss frequently ac company chronic renal failure (CRF). Although multiple metabolic changes occur during CRF, a bulk of evidence indicates that the decrease in caloric intake plays a major role in CRF-induced weight loss. Recently, it has been suggested that elevatedplasma leptin concentrations could contribute to anorexia and to downregulation of leptin gene expression in CRF patients. However, in some CRF patients, plasma leptin concentrations have been found to be lower than one could expect. Thus we assumed that inhibition of leptin synthesis plays an important role in the regulation of plasma leptin concentrations in CRF patients. Methods: To test this assumption, the leptin mRNA level in rat white adipose tissue from ad-libitum-fed control (sham operated), pair-fed control (sham operated) and rats with experimentally induced CRF has been measured by Northern blotting analysis. In addition, serum leptin concentration (by radioimmunoassay) was determined in all three groups of animals. Results: The results of the present study indicate that in experimental CRF the leptinmRNA level is decreased by about 50% as compared to the sham-operated animals (ad-libitum-fed and pair-fed controls). The mean serum leptin concentration in CRF rats was essentially similar to the leptin concentration in sham-operated ones. Conclusion: The data obtained suggest that in CRF animals the serum leptin concentration might be affected not only by the decrease in leptin removal in the kidney, but also by the decrease in leptin secretion from adipose tissue. Furthermore, the results of the study suggest that leptin may be only one of many factors involved in the pathogenesis of malnutrition associated with CRF. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:20:54