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Titolo:
Renal and urinary glycosaminoglycans in an experimental model of chronic renal failure in rats
Autore:
Michelacci, YM; Cadaval, RAM; Rovigatti, RM; Kohlman, O;
Indirizzi:
Univ Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, Disciplina Biol Mol, BR-04044020 Sao Paulo, SP, Brazil Univ Fed Sao Paulo Sao Paulo SP BrazilBR-04044020 BCao Paulo, SP, Brazil Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Nefrol, Dept Med, BR-04044020 Sao Paulo, SP, Brazil Univ Fed Sao Paulo Sao Paulo SP Brazil BR-04044020 BCao Paulo, SP, Brazil
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 1, volume: 9, anno: 2001,
pagine: 40 - 48
SICI:
1018-7782(2001)9:1<40:RAUGIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR BASEMENT-MEMBRANE; HEPARAN-SULFATE PROTEOGLYCAN; ACIDIC MUCOPOLYSACCHARIDES; FLAVOBACTERIUM-HEPARINUM; GEL ELECTROPHORESIS; CELL RECOGNITION; MATRIX; DECORIN; TISSUES; DISEASE;
Keywords:
glycosaminoglycans; kidney; glomerulus; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Michelacci, YM Univ Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, Disciplina Biol Mol, Rua Tres Maio 100, BR-04044020 Sao Paulo, SP, Brazil Univ Fed Sao Paulo Rua Tres Maio 100 Sao Paulo SP Brazil BR-04044020 BC
Citazione:
Y.M. Michelacci et al., "Renal and urinary glycosaminoglycans in an experimental model of chronic renal failure in rats", EXP NEPHROL, 9(1), 2001, pp. 40-48

Abstract

The present paper reports the glomerular and renal individual glycosaminoglycan levels in an experimental model of chronic renal failure (CRF) that was induced in Wistar rats by five-sixths mass ablation. Glycemia, body weight, blood systolic pressure and urinary excretions of creatinine, albumin and glycosaminoglycans were measured for 12 weeks. At the end of the experiment, the weight and the glycosaminoglycan composition of the kidneys were determined. In control rats, heparan sulfate was the main glycosaminoglycan found both in whole kidney and isolated glomeruli, with trace amounts of dermatan sulfate. Isolated glomeruli presented higher heparan sulfate concentrations than whole kidney (expressed as mg/g dry weight). In CRF rats, albuminuria appeared from the 2 week on, and dermatan sulfate and chondroitin sulfate contents of the kidney increased, whereas heparan sulfate levels remained unaltered. Changes in urine glycosaminoglycans (heparan sulfate, chondroitin sulfate and dermatan sulfate) were not statistically significant. The increase in glomerular dermatan sulfate and chondroitin sulfate observedin this experimental model could be related to the mechanisms involved in the glomerulosclerosis and proteinuria that occur in CRF. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:27:25