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Titolo:
Rationale for the luminal provision of butyrate in intestinal diseases
Autore:
Wachtershauser, A; Stein, J;
Indirizzi:
Univ Frankfurt, Med Klin 2, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 n 2, D-60590 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUTRITION
fascicolo: 4, volume: 39, anno: 2000,
pagine: 164 - 171
SICI:
1436-6207(200008)39:4<164:RFTLPO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN FATTY-ACIDS; CELL-LINE; SODIUM-BUTYRATE; COLONIC MUCOSA; ABSORPTION; FERMENTATION; METABOLISM; COLITIS; HINDGUT; CANCER;
Keywords:
butyrate; differentiation; inflammatory bowel disease; structured lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, J Univ Frankfurt, Med Klin 2, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 any
Citazione:
A. Wachtershauser e J. Stein, "Rationale for the luminal provision of butyrate in intestinal diseases", EUR J NUTR, 39(4), 2000, pp. 164-171

Abstract

Short chain fatty acids (SCFA), especially butyrate, play central metabolic roles in maintaining the mucosal barrier in the gut. A lack of SCFA, leading to endogenous starvation of enterocytes, may be the cause of ulcerativecolitis and other inflammatory conditions. The main source of SCFA is dietary fibre, but they can also be derived from structured lipids, e.g. tributyrin. Once absorbed by non-ionic diffusion or carrier-mediated anion exchanges, SCFA are either used locally as fuel for the enterocytes or enter the portal bloodstream. Butyrate has been shown to increase wound healing and to reduce inflammation in the small intestine. In the colon, butyrate is thedominant energy source for epithelial cells and affects cellular proliferation and differentiation by yet unknown mechanisms. Recent data suggest that the luminal provision of butyrate may be an appropriate means to improve wound healing in intestinal surgery and to ameliorate symptoms of inflammatory bowel diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 03:55:10