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Titolo:
Increased serum IgA and decreased IgG(3) strongly correlate with increasedserum TGF-beta(1) levels in patients with nonimmune chronic idiopathic neutropenia of adults
Autore:
Papadaki, HA; Palmblad, J; Kapsimali, V; Anagnou, NP; Eliopoulos, GD;
Indirizzi:
Univ Crete, Dept Haematol, Sch Med, Univ Hosp Heraklion, Heraklion, Crete,Greece Univ Crete Heraklion Crete Greece osp Heraklion, Heraklion, Crete,Greece Huddinge Univ Hosp, Karolinska Inst, Dept Med, Div Haematol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 tol, S-14186 Huddinge, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 65, anno: 2000,
pagine: 237 - 244
SICI:
0902-4441(200010)65:4<237:ISIADI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; MARROW STROMAL CELLS; AUTOIMMUNE NEUTROPENIA; B-CELLS; INVITRO;
Keywords:
nonimmune chronic idiopathic neutropenia of adults; serum immunoglobulins; IL-4; IFN-gamma; IgG subclasses; transforming growth factor-beta(1) (TGF-beta(1));
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Eliopoulos, GD Univ Crete, Dept Haematol, Sch Med, Univ Hosp Heraklion, POB 1352, Heraklion, Crete, Greece Univ Crete POB 1352 Heraklion Crete Greece , Crete, Greece
Citazione:
H.A. Papadaki et al., "Increased serum IgA and decreased IgG(3) strongly correlate with increasedserum TGF-beta(1) levels in patients with nonimmune chronic idiopathic neutropenia of adults", EUR J HAEMA, 65(4), 2000, pp. 237-244

Abstract

Objective: To study the changes in serum immunoglobulins and some closely related pro-inflammatory cytokines in patients with nonimmune chronic idiopathic neutropenia of adults (NI-CINA). Methods. Serum levels of gamma-globulins, IgG, IgA, IgM, IgG subclasses, interleukin-4 (IL-4), interferon-gamma(IFN-gamma) and transforming growth factor-beta(1) (TGF-beta(1)) were evaluated in 83 NI-CINA patients and 65 normal controls using the respective conventional methods. Results: We found that serum gamma-globulin, IgG and IgG(1) levels were all significantly increased in the entire group of patients studied, compared to controls (p <0.001, p < 0.01 and p < 0.01, respectively), while the levels of IgG, were significantly reduced (p<0.001). Serum IgA were increased in patients with severe neutropenia (p< 0.001). No significant changes were noted in serum IgM, IgG(2) and IgG(4) levels. The infrequent occurrence of detectable amounts of IL-4 and IFN-gamma in the serum was similar in both, patients and control subjects. Serum levels of TGF-beta(1) were increased in all groups of patients studied and they correlated inversely with the levels of IgG, (p<0.001) and positively with the levels ofIgA (p<0.001), suggesting the possible involvement of the cytokine in immunoglobulin class switching. Conclusion. Patients with NI-CINA have significant changes in serum immunoglobulins and some inflammation-related cytokines. These findings provide additional evidence for the existence of an unrecognized low-grade chronic inflammatory process in NI-CINA patients and coroborate our previously reported suggestion for the possible involvement of this inflammation in the pathogenesis of neutropenia in the affected subjects.

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Documento generato il 09/04/20 alle ore 20:03:54