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Titolo:
Etiology of neuroanatomical correlates of reading disability
Autore:
Alarcon, M; Pennington, BF; Filipek, PA; DeFries, JC;
Indirizzi:
Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA90095 USA Univ Denver, Dept Psychol, Denver, CO 80208 USA Univ Denver Denver CO USA80208 enver, Dept Psychol, Denver, CO 80208 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 , Dept Pediat, Irvine, CA 92717 USA Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 nst Behav Genet, Boulder, CO 80309 USA
Titolo Testata:
DEVELOPMENTAL NEUROPSYCHOLOGY
fascicolo: 3, volume: 17, anno: 2000,
pagine: 339 - 360
SICI:
8756-5641(2000)17:3<339:EONCOR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-REGRESSION ANALYSIS; QUANTITATIVE-TRAIT LOCUS; DEVELOPMENTAL DYSLEXIA; BRAIN MORPHOLOGY; CORPUS-CALLOSUM; PLANUM-TEMPORALE; NORMAL READERS; CHROMOSOME 6P; SURFACE-AREA; TWIN DATA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Alarcon, M Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Neurol, 710 Westwood Plaza,Room B-105, Los Angeles, CA 90095 USA Univ Calif Los Angeles710 Westwood Plaza,Room B-105 Los Angeles CA USA 90095
Citazione:
M. Alarcon et al., "Etiology of neuroanatomical correlates of reading disability", DEV NEUROPS, 17(3), 2000, pp. 339-360

Abstract

The heritable nature of reading disability has been well documented (DeFries & Alarcon, 1996), and possible abnormalities of brain structures have been associated with the disorder (Filipek, 1995). However, the etiology of individual differences in morphological brain measures has not been examinedextensively. The purpose of this study was to apply behavioral genetic methods to assess the etiology of individual differences in neuroanatomical structures. Measures of reading performance, cognitive ability, and magnetic resonance imaging scans were obtained from 25 monozygotic (MZ) and 23 same-sex dizygotic (DZ) twin pairs with reading disability, and 9 MZ and 9 DZ control twin pairs participating in the Colorado Learning Dis-abilities Research Center. Results obtained from multiple regression analyses (DeFries & Fulker, 1985, 1988) of these twin data indicated that individual differencesin the size of most cortical and subcortical structures were largely due to heritable influences. Moreover, estimates of heritability did not change appreciably after controlling for IQ and total brain size.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:33:33