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Titolo:
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression
Autore:
Miquerol, L; Langille, BL; Nagy, A;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Univ Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada Univ HlthNetwork Toronto ON Canada M5G 2C4 , Toronto, ON M5G 2C4, Canada Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 Genet, Toronto, ON M5S 1A8, Canada
Titolo Testata:
DEVELOPMENT
fascicolo: 18, volume: 127, anno: 2000,
pagine: 3941 - 3946
SICI:
0950-1991(200009)127:18<3941:EDIDBM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA STABILITY; CARDIAC DEVELOPMENT; TYROSINE KINASE; NEUREGULIN RECEPTOR; LIMB ISCHEMIA; HYPOXIA; VEGF; MICE; ANGIOGENESIS; CELLS;
Keywords:
vascular endothelial growth factor; gene regulation; cardiogenesis; coronary development; septation; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nagy, A Mt Sinai Hosp, Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 G 1X5, Canada
Citazione:
L. Miquerol et al., "Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression", DEVELOPMENT, 127(18), 2000, pp. 3941-3946

Abstract

Previous work has shown that heterozygocity for a null mutation of the VEGF-A gene, resulting in a 50% reduction in VEGF-A expression, is embryonic lethal at embroyonic day (E) 9.5 in mice. We now show that two- to threefoldoverexpression of VEGF-A from its endogenous locus results in severe abnormalities in heart development and embryonic lethality at E12.5-E14. The mutant embryos displayed an attenuated compact layer of myocardium, overproduction of trabeculae, defective ventricular septation and abnormalities in remodeling of the outflow track of the heart. In addition, aberrant coronary development was characterized by formation of oversized epicardial vessels,apparently through vasculogenesis. We infer that embryonic survival requires a narrow window of VEGF-A expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:08:03