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Titolo:
Impact of lactic acid fermentation of carbohydrates in the large intestineon the pathogenesis of acute lactic acidosis of cattle.
Autore:
Zust, J; Pestevsek, U; Vengust, A;
Indirizzi:
Univ Ljubljana, Fak Vet Med, Inst Ernahrungspathol Tiere, SLO-1000 Ljubljana, Slovenia Univ Ljubljana Ljubljana Slovenia SLO-1000 SLO-1000 Ljubljana, Slovenia
Titolo Testata:
DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT
fascicolo: 9, volume: 107, anno: 2000,
pagine: 359 - 363
SICI:
0341-6593(200009)107:9<359:IOLAFO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
GER
Soggetto:
STARCH DIGESTION; RUMINANTS; STEERS;
Keywords:
gastrointestinal disfunctions; large intestine; lactic acid fermentation; lactic acidosis; acid-base balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Zust, J Univ Ljubljana, Fak Vet Med, Inst Ernahrungspathol Tiere, Gerbiceva 60, SLO-1000 Ljubljana, Slovenia Univ Ljubljana Gerbiceva 60 Ljubljana Slovenia SLO-1000 Slovenia
Citazione:
J. Zust et al., "Impact of lactic acid fermentation of carbohydrates in the large intestineon the pathogenesis of acute lactic acidosis of cattle.", DEUT TIER W, 107(9), 2000, pp. 359-363

Abstract

Microbial and fermentation changes in the ingesta of the large intestine and their influence on the pathogenesis of acute lactic acidosis were studied in 4 cows fitted with permanent cannulas in the ileum and cecum. Feed mixture containing 65 % of maize was infused into the cecum for several days in amounts of 2 and 4 kg per day. The daily amount was divided in 8 equal portions and given with 31 of warm physiologic saline solution. During the period of ad libitum feeding of hay, the pH Values in cecal digesta were 7,4 to 7,6 and the amount of total Volatile fatty acids 40-60 mmol/kg with highmolar percentage (87-90 mol%) of acetic acid. As to lactic acid only the L(+) lactic isomer was found in a concentration of about 0,4 mmol/kg. Infusion of low amounts of starch induced mild lactic acid fermentation in the cecum associated with a pronounced increase in the concentration of L(+) and D (-) lactic acid to peak levels of 80 +/- 10 mmol/kg and 7 +/- 1 mmol/kg, respectively. tactic acid fermentation ceased within 2 to 3 days indicatingthat the gut microflora had adapted to the starch infusion. Slight decreases of blood pH and bicarbonates in blood as well as a moderate increase of netto acid-base excretion in urine indicated mild changes of acid-base balance, but clinically no pathological symptoms were observed. Higher amounts of infused starch caused pronounced lactic acid production in the large intestine which persisted throughout the experiment. Peak L(+) and D(-) lacticacid concentration in cecal digesta reached on the average 137 +/- 16 mmol/kg and 45 +/- 7 mmol/kg respectively. Significant decreases of blood pH values from 7,41 +/- 0,02 to 7,18 +/- 0,08 (P < 0,001), actual bicarbonate from 28,2 +/- 3,2 to 11,0 +/- 2,6 mmol/l (P < 0,001) and base excess from 3,9+/- 3,6 to -15,2 +/- 3,8 mmol/l (P < 0,001) were observed. D (-) lactic acid concentration in blood increased to 3,2 +/- 0,4 mmol/l, but L(+) lactic acid values remained unchanged under 1 mmol/l. Clear clinical symptoms of indigestion and intoxication characterized by severe inappetence, ruminal stasis and general weakness were also observed. Typical clinical symptoms of disease as well as blood and urine changes in acid-base balance indicated that lactic acid fermentation in the large intestine contributes considerably to the pathogenesis of acute ruminant lactic acidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:52:00