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Titolo:
Differentiation between Merkel cell carcinoma and malignant melanoma: An immunohistochemical study
Autore:
Kontochristopoulos, GJ; Stavropoulos, PG; Krasagakis, K; Goerdt, S; Zouboulis, CC;
Indirizzi:
A Syngros Hosp, Dept Dermatol 2, Athens 16121, Greece A Syngros Hosp Athens Greece 16121 Dept Dermatol 2, Athens 16121, Greece Free Univ Berlin, Univ Med Ctr Benjamin Franklin, Dept Dermatol, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 Dermatol, D-1000 Berlin, Germany
Titolo Testata:
DERMATOLOGY
fascicolo: 2, volume: 201, anno: 2000,
pagine: 123 - 126
SICI:
1018-8665(2000)201:2<123:DBMCCA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROENDOCRINE CARCINOMA; SKIN; TUMOR; CYTOKERATIN-20; ANTIBODIES; DIAGNOSIS; NEOPLASMS; FEATURES; MARKER;
Keywords:
cutaneous neoplasms; neuroendocrine tumor; neuron-specific enolase; cytokeratin 20; antimelanoma antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kontochristopoulos, GJ A Syngros Hosp, Dept Dermatol 2, 5 I Dragoumi Str, Athens 16121, Greece A Syngros Hosp 5 I Dragoumi Str Athens Greece 16121
Citazione:
G.J. Kontochristopoulos et al., "Differentiation between Merkel cell carcinoma and malignant melanoma: An immunohistochemical study", DERMATOLOGY, 201(2), 2000, pp. 123-126

Abstract

Background Although Merkel cell carcinoma (MCC) exhibits specific clinicaland histologic features, differentiation from other cutaneous neoplasms, such as lymphoma, metastatic oat cell carcinoma and malignant melanoma (MM),may sometimes be difficult. Objective: The aim of our study was to immunohistochemically differentiate MCC from MM. Methods: Paraffin sections from 6cases of primary MCC and 6 cases of primary MM were investigated. For immunostaining, the APAAP method was used. Results: Neuron-specific enolase waspositive in all cases of MCC, as well as in 2 cases of MM. Marked positivity for cytokeratins 18, 20 and chromogranin A was observed in the MCC group, whereas a complete absence of expression of these th ree markers was noted in the MM group. Immunostaining with HMB45 and NKI/C3 was positive in allcases of MM and negative in all cases of MCC. S-100 protein was positive in all but 1 case of MM. In contrast, only 1 case of MCC reacted with S-100 protein. Conclusion: Our results underline the role of immunohistochemistryin the diagnosis and differential diagnosis of MCC. In particular, the combination of neuron-specific enolase, cytokeratins 18, 20 and chromogranin Apositivity for MCC and HMB45, NKI/C3 and S-100 protein positivity for MM is of great value in the distinction between these two cutaneous neoplasms. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:22:57