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Titolo:
Regional distribution and kinetics of inhaled pharmaceuticals
Autore:
Berridge, MS; Lee, ZH; Heald, DL;
Indirizzi:
Univ Hosp Cleveland, Dept Radiol, Cleveland, OH 44104 USA Univ Hosp Cleveland Cleveland OH USA 44104 adiol, Cleveland, OH 44104 USA Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Rhone Poulenc Rorer Pharmaceut Inc, Collegeville, PA 19426 USA Rhone Poulenc Rorer Pharmaceut Inc Collegeville PA USA 19426 PA 19426 USA
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 16, volume: 6, anno: 2000,
pagine: 1631 - 1651
SICI:
1381-6128(200011)6:16<1631:RDAKOI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; AEROSOL DEPOSITION PATTERN; EXTREMELY SLOW INHALATIONS; METERED-DOSE INHALERS; CEREBRAL BLOOD-FLOW; GAMMA-SCINTIGRAPHY; LUNG DEPOSITION; PULMONARY DEPOSITION; HEALTHY-SUBJECTS; DRUG-DELIVERY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, MS Univ Hosp Cleveland, Dept Radiol, 11100 Euclid Ave, Cleveland, OH 44104 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA 44104 A
Citazione:
M.S. Berridge et al., "Regional distribution and kinetics of inhaled pharmaceuticals", CUR PHARM D, 6(16), 2000, pp. 1631-1651

Abstract

Drug biodistribution is often secondary to drug action. However, drugs that have a topical action and are deposited into the airway by inhalation aredependent on effective deposition at the intended site of action. Measurement of the distribution of such drugs in the airway is a useful tool. Distribution data can help to interpret clinical results, to evaluate products relative to each other, to optimize a new drug formulation, and to choose effective drug delivery methods. Imaging of radiotracers is the only means available to measure drug deposition throughout the lungs, nasal passages, and sinuses. There are several approaches to imaging drug deposition, Planar imaging has been the most used method, but SPECT and PET imaging are beginning to be applied effectively. The properties of non-drug tracers, labelingof drugs, evaluation of distribution patterns, and quantification of deposited drugs are important issues that have been addressed. Imaging has been shown to be a powerful technique to evaluate and to speed development of inhaled drugs. This review explores the most recent advances and issues with an emphasis on drug development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 08:19:49