Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PET studies of brain monoamine transporters
Autore:
Laakso, A; Hietala, J;
Indirizzi:
Orion Corp, CNS Drugs, Clin Res, Orion Pharma, FIN-20101 Turku, Finland Orion Corp Turku Finland FIN-20101 rion Pharma, FIN-20101 Turku, Finland Univ Turku, Dept Pharmacol & Clin Pharmacol, Turku, Finland Univ Turku Turku Finland ept Pharmacol & Clin Pharmacol, Turku, Finland Univ Turku, Dept Psychiat, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Psychiat, Turku, Finland Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 16, volume: 6, anno: 2000,
pagine: 1611 - 1623
SICI:
1381-6128(200011)6:16<1611:PSOBMT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; I-123 BETA-CIT; LIVING HUMAN-BRAIN; HUMAN DOPAMINE TRANSPORTER; REUPTAKE SITE DENSITIES; SEROTONIN-TRANSPORTER; IN-VIVO; PARKINSONS-DISEASE; BINDING-SITES; NONHUMAN-PRIMATES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Laakso, A Orion Corp, CNS Drugs, Clin Res, Orion Pharma, POB 425, FIN-20101 Turku, Finland Orion Corp POB 425 Turku Finland FIN-20101 20101 Turku, Finland
Citazione:
A. Laakso e J. Hietala, "PET studies of brain monoamine transporters", CUR PHARM D, 6(16), 2000, pp. 1611-1623

Abstract

Monoamine transporters are proteins mainly located on nerve terminals of dopaminergic, noradrenergic and serotonergic neurons. They are members of a larger sodium dependent transporter family and represent a major mechanism terminating the action of released neurotransmitter in the synaptic cleft. In addition to being important target molecules for many antidepressive drugs and substances of abuse, transporter proteins are good markers for the integrity of monoaminergic innervation. Therefore, there is a growing interest for in vivo imaging studies using positron emission tomography (PET) or single photon emission computed tomography (SPECT) and ligands selective for monoamine transporters. In this review, the use of monoamine transporter ligands (or tracers) for imaging studies of cocaine dependence, neurodegenerative diseases and mechanism of antidepressant drug action is discussed, with special focus on the use of PET for evaluating possible new pharmacological innovations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:53:05