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Titolo:
ABC transporters in cellular lipid trafficking
Autore:
Schmitz, G; Kaminski, WE; Orso, E;
Indirizzi:
Univ Regensburg, Inst Clin Chem & Lab Med, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 5, volume: 11, anno: 2000,
pagine: 493 - 501
SICI:
0957-9672(200010)11:5<493:ATICLT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING CASSETTE TRANSPORTER-1; DISEASE GENE ABCR; TRANSMEMBRANE CONDUCTANCE REGULATOR; FAMILIAL INTRAHEPATIC CHOLESTASIS; DUBIN-JOHNSON-SYNDROME; MAP KINASE CASCADE; TANGIER-DISEASE; P-GLYCOPROTEIN; STARGARDT-DISEASE; PLASMA-MEMBRANE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Schmitz, G Univ Regensburg, Inst Clin Chem & Lab Med, Franz Josef Str Allee 11, D-93042 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93042
Citazione:
G. Schmitz et al., "ABC transporters in cellular lipid trafficking", CURR OP LIP, 11(5), 2000, pp. 493-501

Abstract

ATP-binding cassette (ABC) transporters constitute a group of evolutionaryhighly conserved cellular transmembrane transport proteins. Recent work has implicated ABC transporters in cellular transmembrane lipid transport andhereditary diseases have been causatively linked to defective ABC transporters translocating lipid compounds. The emerging concept that a defined subset of ABC transporters is intimately involved in cellular lipid trafficking has recently been substantiated convincingly by the finding that ABCA1 plays a central role in the regulation of HDL metabolism and macrophage targeting to the RES or the vascular wall. Differentiation dependent expression of a large number of ABC transporters in monocytes/macrophages and their regulation by sterol flux render these transporter molecules potentially critical players in atherogenesis and other chronic inflammatory diseases, CurrOpin Lipidol 11:493-501. (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:50:04