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Titolo:
Detection of alloantibodies against non-HLA antigens in kidney transplantation by flow cytometry
Autore:
Rodriguez, PC; Arroyave, IH; Mejia, G; Garcia, LF;
Indirizzi:
Univ Antioquia, Fac Med, Dept Med Interna, Grp Inmunol Celular & Inmunogenet, Medellin, Colombia Univ Antioquia Medellin Colombia ular & Inmunogenet, Medellin, Colombia
Titolo Testata:
CLINICAL TRANSPLANTATION
fascicolo: 5, volume: 14, anno: 2000,
pagine: 472 - 478
SICI:
0902-0063(200010)14:5<472:DOAANA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOTHELIAL CELLS; VASCULAR REJECTION; RENAL-ALLOGRAFTS; ANTIBODIES; RECIPIENTS;
Keywords:
accelerated rejection; endothelium/monocyte; flow cytometry crossmatch; hyperacute rejection; kidney transplantation; non-major histocompatibility complex antigens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, LF Univ Antioquia, Fac Med, Dept Med Interna, Grp Inmunol Celular & Inmunogenet, Medellin, Colombia Univ Antioquia Medellin Colombia nogenet, Medellin, Colombia
Citazione:
P.C. Rodriguez et al., "Detection of alloantibodies against non-HLA antigens in kidney transplantation by flow cytometry", CLIN TRANSP, 14(5), 2000, pp. 472-478

Abstract

The presence of alloantibodies against human leucocyte antigen (HLA)-I andHLA-II antigens has been associated with hyperacute and accelerated graft rejections. However, occasionally these rejections occur in patients without donor-specific anti-HLA antibodies, suggesting the presence of other antigenic complexes that are shared by the graft and other cell populations. Usually, these antibodies are not routinely studied and their role in graft rejection is poorly understood. For this reason, we tested, by flow cytometry, the presence of panel-reactive alloantibodies (PRA) using different cellpopulations in 30 pre-transplant sera of kidney graft recipients. The patients studied had or had not hyperacute and accelerated rejection episodes (HARE) and did not have alloantibodies against HLA of their specific donors. We found that IgG and IgM alloantibodies directed against HLA-I antigens, different to the HLA-I antigens of the specific donors, as well as IgG against endothelium/monocyte antigens, IgM against platelets, and IgM against Tcells are significantly associated with HARE, independently of the percentage of PRA. Our findings suggest that the detection of antibodies by flow cytometry against non-major histocompatibilty complex antigens may be usefulas a pre-transplant crossmatch in living related donor kidney transplants to diminish the incidence of HARE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:27:03