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Titolo:
Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function
Autore:
Tzianabos, AO;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Channing Lab, Boston, MA 02115 USA
Titolo Testata:
CLINICAL MICROBIOLOGY REVIEWS
fascicolo: 4, volume: 13, anno: 2000,
pagine: 523 -
SICI:
0893-8512(200010)13:4<523:PIATAS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GLUCAN RECEPTOR; EXPERIMENTAL INTRAABDOMINAL SEPSIS; PROTEIN-BOUND POLYSACCHARIDE; CANDIDA-ALBICANS MANNAN; RISK SURGICAL PATIENTS; T-CELL ACTIVATION; KAPPA-B-LIKE; BACTEROIDES-FRAGILIS; PGG-GLUCAN; ABSCESS FORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Tzianabos, AO Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Harvard Univ 181 Longwood Ave BostonMA USA 02115 02115 USA
Citazione:
A.O. Tzianabos, "Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function", CLIN MICROB, 13(4), 2000, pp. 523

Abstract

Polysaccharide immunomodulators were first discovered over 40 years ago. Although very few have been rigorously studied, recent reports have revealedthe mechanism of action and structure-function attributes of some of thesemolecules. Certain polysaccharide immunomodulators have been identified that have profound effects in the regulation of immune responses during the progression of infectious diseases, and studies have begun to define structural aspects of these molecules that govern their function and interaction with cells of the host immune system. These polymers can influence innate and cell-mediated immunity through interactions with T cells, monocytes, macrophages, and polymorphonuclear lymphocytes. The ability to modulate the immune response in an appropriate way can enhance the host's immune response to certain infections. In addition this strategy can be utilized to augment current treatment regimens such as antimicrobial therapy that are becoming less efficacious with the advent of antibiotic resistance. This review focuses on recent studies that illustrate the structural and biologic activities of specific polysaccharide immunomodulators and outlines their potential for clinical use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:44:48