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Titolo:
Prophylaxis for opportunistic infections in an era of effective antiretroviral therapy
Autore:
Powderly, WG;
Indirizzi:
Washington Univ, Sch Med, Dept Med, Div Infect Dis, St Louis, MO 63110 USAWashington Univ St Louis MO USA 63110 Infect Dis, St Louis, MO 63110 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 2, volume: 31, anno: 2000,
pagine: 597 - 601
SICI:
1058-4838(200008)31:2<597:PFOIIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; PNEUMOCYSTIS-CARINII PNEUMONIA; AVIUM COMPLEX INFECTION; CYTOMEGALOVIRUS RETINITIS; MAINTENANCE THERAPY; HIV-1 INFECTION; AIDS; DISCONTINUATION; ZIDOVUDINE; LAMIVUDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Powderly, WG Washington Univ, Sch Med, Dept Med, Div Infect Dis, Campus Box 8051,660 S Euclid Ave, St Louis, MO 63110 USA Washington Univ Campus Box 8051,660 S Euclid Ave St Louis MO USA 63110
Citazione:
W.G. Powderly, "Prophylaxis for opportunistic infections in an era of effective antiretroviral therapy", CLIN INF D, 31(2), 2000, pp. 597-601

Abstract

Potent antiretroviral treatment is associated with dramatic improvements in immune function in many human immunodeficiency virus-infected patients. This has led to new US Public Health Service/Infectious Diseases Society of America guidelines that suggest that in certain circumstances (primary prophylaxis for Pneumocystis carinii pneumonia and disseminated Mycobacterium avium complex infection, and secondary prophylaxis for cytomegalovirus retinitis), antimicrobial prophylaxis can be discontinued for patients whose CD4T-cell counts rise above threshold levels for at least 3-6 months. The newguidelines are probably too conservative, and effective antiretroviral treatment almost certainly provides protection against all major opportunisticpathogens. Therefore, in the future, specific prophylaxis will be needed only for those patients who do not benefit from or fail to adhere to the current more effective treatment of human immunodeficiency virus infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:27:17