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Titolo:
Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population
Autore:
Hatanaka, Y; Kamino, K; Fukuo, K; Mitsuda, N; Nishiwaki-Ueda, Y; Sato, N; Satoh, T; Yamamoto, H; Yoneda, H; Imagawa, M; Miki, T; Ohta, S; Ogihara, T;
Indirizzi:
Osaka Univ, Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 atr Med, Suita, Osaka 5650871, Japan Nippon Med Sch, Inst Gerontol, Dept Biochem & Cell Biol, Kanagawa 2118533,Japan Nippon Med Sch Kanagawa Japan 2118533 Cell Biol, Kanagawa 2118533,Japan Kanazawa Med Univ, Dept Geriatr Med, Kanazawa, Ishikawa 9200293, Japan Kanazawa Med Univ Kanazawa Ishikawa Japan 9200293 Ishikawa 9200293, Japan Osaka Univ, Sch Med, Dept Anat & Neurosci, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 eurosci, Suita, Osaka 5650871, Japan Osaka Municipal Kohsaiin Hosp, Dept Med, Suita, Osaka 5650873, Japan OsakaMunicipal Kohsaiin Hosp Suita Osaka Japan 5650873 ka 5650873, Japan Osaka Med Coll, Dept Neuropsychiat, Takatsuki, Osaka 569, Japan Osaka Med Coll Takatsuki Osaka Japan 569 iat, Takatsuki, Osaka 569, Japan Hyogo Prefectural Amagasaki Hosp, Dept Neuropsychiat & Neurol, Amagasaki, Hyogo 660, Japan Hyogo Prefectural Amagasaki Hosp Amagasaki Hyogo Japan 660 ogo 660, Japan Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 7920204, Japan Ehime Univ Matsuyama Ehime Japan 7920204 Matsuyama, Ehime 7920204, Japan
Titolo Testata:
CLINICAL GENETICS
fascicolo: 4, volume: 58, anno: 2000,
pagine: 319 - 323
SICI:
0009-9163(200010)58:4<319:LDLRPG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E; LRP GENE; ASSOCIATION; DEMENTIA; EXON-3;
Keywords:
Alzheimer's disease; apolipoprotein E; association; genetic risk modifier; Japanese population; LDL receptor-related protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fukuo, K Osaka Univ, Sch Med, Dept Geriatr Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
Y. Hatanaka et al., "Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population", CLIN GENET, 58(4), 2000, pp. 319-323

Abstract

Low density lipoprotein (LDL) receptor-related protein (LRP) gene polymorphisms located in the 5' region and in exon 3, and the apolipoprotein E (APOE) genotype were determined in 100 Japanese patients affected by late-onsetAlzheimer's disease (AD). We matched 246 controls for age and found no association between the polymorphism located in the 5' region of the LRP gene. The distribution of LRP exon 3 genotypes and alleles did not differ between AD and the control groups. However, the frequency of T allele in the Alzheimer's group having APOE-epsilon 4 was lower than that in the control group having APOE-epsilon 4, but it was only marginally significant (p = 0.022). Age of onset was significantly younger in the patients with CC genotype than those carrying the T allele (p = 0.03), and this trend was more evidentamong non-APOE-epsilon 4 carriers (p = 0.008). These results support the possibility that ApoE and LRP may contribute to the development of AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:28:48