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Titolo:
Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction
Autore:
Apple, FS; Anderson, FP; Collinson, P; Jesse, RL; Kontos, MC; Levitt, MA; Miller, EA; Murakami, MM;
Indirizzi:
Hennepin Cty Med Ctr, Clin Labs 812, Dept Lab Med & Pathol, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr Minneapolis MN USA 55415 , Minneapolis, MN 55415 USA Med Coll Virginia, Dept Pathol, Richmond, VA 23225 USA Med Coll Virginia Richmond VA USA 23225 pt Pathol, Richmond, VA 23225 USA Med Coll Virginia, Dept Med, Richmond, VA 23225 USA Med Coll Virginia Richmond VA USA 23225 Dept Med, Richmond, VA 23225 USA Mayday Univ Hosp, Surrey CR7 7YE, England Mayday Univ Hosp Surrey England CR7 7YE iv Hosp, Surrey CR7 7YE, England Alameda Cty Med Ctr, Dept Emergency Med, Oakland, CA 94602 USA Alameda CtyMed Ctr Oakland CA USA 94602 gency Med, Oakland, CA 94602 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 10, volume: 46, anno: 2000,
pagine: 1604 - 1609
SICI:
0009-9147(200010)46:10<1604:CEOTFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-T; ACUTE CHEST PAIN; CREATINE-KINASE-MB; BEDSIDE ASSAY; SERUM; MYOGLOBIN; TRIAGE; MARKER; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Apple, FS Hennepin Cty Med Ctr, Clin Labs 812, Dept Lab Med & Pathol, 701 Pk Ave, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr 701 Pk Ave Minneapolis MN USA 55415 415 USA
Citazione:
F.S. Apple et al., "Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction", CLIN CHEM, 46(10), 2000, pp. 1604-1609

Abstract

Background: Validation of whole blood, point-of-rare testing devices for monitoring cardiac markers to aid clinicians in ruling in and ruling out myocardial infarction (MI) is necessary for both laboratory and clinical acceptance. Methods: This study evaluated the clinical diagnostic sensitivity and specificity of the First Medical Cardiac Test device operated by nursing and laboratory personnel that simultaneously measures cardiac troponin I (cTnI), creatine kinase (CK) MB, myoglobin, and total CK on the Alpha Dr analyzer in whole blood for detection of MI. Over a 6-month period, 369 patients initially presenting to the emergency department with chest pain were evaluatedfor MI using modified WHO criteria. Eighty-nine patients (24%) were diagnosed with MI. Results: In whole blood samples collected at admission and at 3- to 6-h intervals over 24 h, ROC curve-determined MI decision limits were as follows:cTnI, 0.4 mu g/L; CKMB, 7.0 mu g/L; myoglobin, 180 mu g/L; total CK, 190 mu g/L. Based on peak concentrations within 24 h after presentation, the following sensitivities (+/- 95% confidence intervals) were found: cTnI, 93% +/- 5.5%; myoglobin, 81% +/- 9.7%; CKMB, 90% +/- 6.3%; total CK, 86% +/- 7.5%. Sensitivities were maximal at >90% for both cTnI and CKMB at >12 h in MIpatients, without differences between ST-segment elevation and non-ST-segment elevation MI patients. Conclusions: The First Medical point-of-care device provides cardiac marker assays that can be used by laboratories and clinicians in a variety of hospital settings for ruling in and ruling out MI. (C) 2000 American Association for Clinical Chemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:01:18