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Titolo:
Characterization and regulation of tachykinin receptors in the nucleus tractus solitarius
Autore:
Mazzone, SB; Geraghty, DP;
Indirizzi:
Univ Tasmania, Sch Biomed Sci, Launceston, Tas 7250, Australia Univ Tasmania Launceston Tas Australia 7250 unceston, Tas 7250, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 11, volume: 27, anno: 2000,
pagine: 939 - 942
SICI:
0305-1870(200011)27:11<939:CAROTR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT SPINAL-CORD; SUBSTANCE-P; RESPIRATORY RESPONSE; NK1 RECEPTOR; IN-VITRO; HYPOXIA; STIMULATION; RELEASE; BINDING;
Keywords:
autoradiography; microinjection; nucleus tractus solitarius; respiration; tachykinin receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Geraghty, DP Univ Tasmania, Sch Biomed Sci, Locked Bag 1-320, Launceston, Tas 7250, Australia Univ Tasmania Locked Bag 1-320 Launceston Tas Australia7250
Citazione:
S.B. Mazzone e D.P. Geraghty, "Characterization and regulation of tachykinin receptors in the nucleus tractus solitarius", CLIN EXP PH, 27(11), 2000, pp. 939-942

Abstract

1. The characteristics, localization and regulation of tachykinin receptors in the rat nucleus tractus solitarius (NTS) involved in respiratory control were investigated using a combination of in vivo microinjection and in vitro autoradiographic techniques.2. Microinjection of receptor-selective tachykinin agonists and antagonists into the NTS of urethane-anaesthetized rats suggests that stimulation of NK1 and NK3 receptors increases tidal volume, whereas NK2 and NK3 receptor activation produces a bradypnoea.3. Depletion of NK1 receptors in the NTS due to either ageing or acute hypoxia correlates with a markedly reduced respiratory response to substance P. In contrast, chemical ablation of sensory neurons by neonatal capsaicin administration dramatically increases the respiratory response to a variety of NK1, NK2 and NK3 agonists.4. These studies suggest that all three tachykinin receptors are present in the rat NTS and that these receptors are subject to both acute and chronic regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:12:39