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Titolo:
Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats
Autore:
Yamasaki, Y; Watanabe, TK; Okuno, S; Ono, T; Oga, K; Mizoguchi-Miyakita, A; Goto, Y; Shinomiya, H; Momota, H; Miyao, H; Hayashi, I; Asai, T; Suzuki, M; Harada, Y; Hishigaki, H; Wakitani, S; Takagi, T; Nakamura, Y; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710192 7710192, Japan Osaka Minami Natl Hosp, Dept Orthopaed Surg, Osaka, Japan Osaka Minami Natl Hosp Osaka Japan p, Dept Orthopaed Surg, Osaka, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Database, Tokyo, Japan Univ Tokyo Tokyo Japan Human Genome, Lab Genome Database, Tokyo, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan UnivTokyo Tokyo Japan Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 11, volume: 27, anno: 2000,
pagine: 881 - 886
SICI:
0305-1870(200011)27:11<881:QTLFLM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; TOKUSHIMA FATTY RATS; RADIATION HYBRID MAP; GENETIC DISSECTION; RISK FACTOR; MODEL; OBESITY; HYPERTRIGLYCERIDEMIA; LINKAGE; SERUM;
Keywords:
hyperlipidaemia; OLETF rat; quantitative trait loci analysis; type II diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, TK Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 Kagasuno, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Tokushima Japan 7710192
Citazione:
Y. Yamasaki et al., "Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats", CLIN EXP PH, 27(11), 2000, pp. 881-886

Abstract

1. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a model of type IIdiabetes with accompanying dyslipidaemia and obesity.2. To define chromosomal intervals associated with obesity (abdominal fat weight and plasma leptin levels), dyslipidaemia (plasma triglyceride, cholesterol and free fatty acids) and hyperglycaemia (plasma glucose levels), wehave performed genome-wide quantitative traits loci (QTL) analyses of 115 male OLETF x (OLETF x Fischer 344) backcross animals at 16 weeks of age.3. The Diabetes Mellitus OLETF type I (Dmo1) locus on rat chromosome 1 showed statistically significant involvement in elevations of plasma levels oftriglycerides (P = 4.87 x 10(-6) at D1Rat90) and total cholesterol (P = 1.16 x 10(-5) at D1Rat306).4. No other loci produced significant linkage to these observed phenotypes.5. These analyses have confirmed the importance of Dmo1 in lipid homeostasis at younger ages as well as during overt diabetes, which appears later. Thus, alterations at the Dmo1 locus are a major risk factor for pathogenesisin the strain, a finding that agrees with physiological studies that indicate a role for dyslipidaemia in the type II diabetic syndrome of OLETF rats.

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Documento generato il 03/06/20 alle ore 08:21:12