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Titolo:
Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids
Autore:
Roman, RJ; Maier, KG; Sun, CW; Harder, DR; Alonso-Galicia, M;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 11, volume: 27, anno: 2000,
pagine: 855 - 865
SICI:
0305-1870(200011)27:11<855:RACAO2>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; THICK ASCENDING LIMB; BOVINE CORONARY-ARTERIES; VASCULAR SMOOTH-MUSCLE; PROTEIN-KINASE-C; DAHL-S RATS; ARACHIDONIC-ACID; NITRIC-OXIDE; OMEGA-HYDROXYLASE; CARBON-MONOXIDE;
Keywords:
blood vessels; cytochrome P450; epoxyeicosatrienoic acids; 20-hydroxyeicosatetraenoic acid; kidney; lung cerebral circulation; potassium channels;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Roman, RJ Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
R.J. Roman et al., "Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids", CLIN EXP PH, 27(11), 2000, pp. 855-865

Abstract

1. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP)-dependentpathways to epoxyeicosatrienoic acids (EET) and 20-hydroxyeicosatetraenoicacid (20-HETE) in the kidney and the peripheral vasculature.2. The present short review summarizes the renal and cardiovascular actions of these important mediators.3. Epoxyeicosatrienoic acids are vasodilators produced by the endothelium that hyperpolarize vascular smooth muscle (VSM) cells by opening Ca2+-activated K+ (K-Ca) channels. 20-Hydroxyeicosatetraenoic acid is a vasoconstrictor that inhibits the opening of K-Ca channels in VSM cells. Cytochrome P4504A inhibitors block the myogenic response of small arterioles to elevations in transmural pressure and autoregulation of renal and cerebral blood flow in vivo. Cytochrome P450 4A blockers also attenuate the vasoconstrictor response to elevations in tissue PO2, suggesting that this system may serve as a vascular oxygen sensor. Nitric oxide and carbon monoxide inhibit the formation of 20-HETE and a fall in 20-HETE levels contributes to the activation of K-Ca channels in VSM cells and the vasodilator response to these gaseous mediators. 20-Hydroxyeicosatetraenoic acid also mediates the inhibitory actions of peptide hormones on sodium transport in the kidney and the mitogenic effects of growth factors in VSM and mesangial cells. A deficiency in the renal production of 20-HETE is associated with the development of hypertension in Dahl salt-sensitive rats.4. In summary, the available evidence indicates that CYP metabolites of AAplay a central role in the regulation of renal, pulmonary and vascular function and that abnormalities in this system may contribute to the pathogenesis of cardiovascular diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:46:15