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Titolo:
Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans
Autore:
Ariyo, AA; Haan, M; Tangen, CM; Rutledge, JC; Cushman, M; Dobs, A; Furberg, CD;
Indirizzi:
Johns Hopkins Univ, Div Cardiovasc Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA iv Cardiovasc Med, Baltimore, MD USA Johns Hopkins Univ, Div Endocrine, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA iv, Div Endocrine, Baltimore, MD USA Univ Calif Davis, Div Cardiovasc Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 v Cardiovasc Med, Davis, CA 95616 USA Univ Calif Davis, Div Epidemiol & Prevent, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 demiol & Prevent, Davis, CA 95616 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Vermont, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA Wake Forest Univ, Dept Publ Hlth Sci, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA
Titolo Testata:
CIRCULATION
fascicolo: 15, volume: 102, anno: 2000,
pagine: 1773 - 1779
SICI:
0009-7322(20001010)102:15<1773:DSAROC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; BLOOD-PRESSURE; FOLLOW-UP; HOPELESSNESS; ASSOCIATION; CHOLESTEROL; PRECURSOR; SURVIVAL; FATIGUE;
Keywords:
risk factors; epidemiology; coronary disease; mortality; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ariyo, AA Johns Hopkins Hosp, Div Cardiovasc, 600 N Wolfe St,Carnegie 568,Baltimore, MD 21287 USA Johns Hopkins Hosp 600 N Wolfe St,Carnegie 568 Baltimore MD USA 21287
Citazione:
A.A. Ariyo et al., "Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans", CIRCULATION, 102(15), 2000, pp. 1773-1779

Abstract

Background-Several epidemiological studies have associated depressive symptoms with cardiovascular disease. We investigated whether depressive symptoms constituted a risk for coronary heart disease (CHD) and total mortality among an apparently healthy elderly cohort. Methods and Results-In a prospective cohort of 5888 elderly Americans (greater than or equal to 65 years) who were enrolled in the Cardiovascular Health Study, 4493 participants who were free of cardiovascular disease at baseline provided annual information on their depressive status, which was assessed using the Depression Scale of the Center for Epidemiological Studies. These 4493 subjects were followed for 6 years for the development of CHD and mortality. The cumulative mean depression score was assessed for each participant up to the time of event (maximum 6-year follow-up). Using time-dependent, proportional-hazards models, the unadjusted hazard ratio associated with every 5-unit increase in mean depression score for the development of CHD was 1.15 (P=0.006); the ratio for all-cause mortality was 1.29 (P<0.0001), In multivariate analyses adjusted for age, race, sex, education, diabetes, hypertension, cigarette smoking, total cholesterol, triglyceride level, congestive heart failure, and physical inactivity, the hazard ratio for CHD was 1.15 (P=0.006) and that for all-cause mortality was 1.16 (P=0.006). Among participants with the highest cumulative mean depression scores, therisk of CHD increased by 40% and risk of death by 60% compared with those who had the lowest mean scores. Conclusions-Among elderly Americans, depressive symptoms constitute an independent risk factor for the development of CHD and total mortality.

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Documento generato il 30/11/20 alle ore 20:01:31