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Titolo:
Platelet Pl(A2) allele and incidence of coronary heart disease - Results from the atherosclerosis risk in communities (ARIC) study
Autore:
Aleksic, N; Juneja, H; Folsom, AR; Ahn, C; Boerwinkle, E; Chambless, LE; Wu, KK;
Indirizzi:
Univ Texas, Sch Med, Div Hematol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 h Med, Div Hematol, Houston, TX 77030 USA Univ Texas, Sch Med, Vasc Biol Res Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Vasc Biol Res Ctr, Houston, TX 77030 USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA Univ Texas, Hlth Sci Ctr, Ctr Human Genet, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 r, Ctr Human Genet, Houston, TX 77030 USA Univ N Carolina, Dept Biostat, Chapel Hill, NC USA Univ N Carolina ChapelHill NC USA na, Dept Biostat, Chapel Hill, NC USA
Titolo Testata:
CIRCULATION
fascicolo: 16, volume: 102, anno: 2000,
pagine: 1901 - 1905
SICI:
0009-7322(20001017)102:16<1901:PPAAIO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; GLYCOPROTEIN IIIA; PIA POLYMORPHISM; ARTERY DISEASE; THROMBOSIS; ACTIVATION; IIB/IIIA; RECEPTOR; MARKERS; ASSOCIATION;
Keywords:
platelets; glycoproteins; coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, KK Univ Texas, Sch Med, Div Hematol, 6431 Fannin,SB 5-016, Houston, TX77030 USA Univ Texas 6431 Fannin,SB 5-016 Houston TX USA 77030 , TX 77030 USA
Citazione:
N. Aleksic et al., "Platelet Pl(A2) allele and incidence of coronary heart disease - Results from the atherosclerosis risk in communities (ARIC) study", CIRCULATION, 102(16), 2000, pp. 1901-1905

Abstract

Background-The major platelet integrin glycoprotein IIb-IIIa plays a primary role in platelet aggregation and acute thrombus formation at the site ofvascular injury. A genetic polymorphism of glycoprotein IIb-IIIa (Pl(A)) has recently been proposed as a potential genetic factor linking to platelethyperaggregability and increased risk of myocardial infarction. Despite numerous, mostly nonprospective studies, the role of this polymorphism as a clinically relevant, inherited risk factor for coronary heart disease (CHD) is still controversial. The purpose of this study was to determine whether Pl(A2) is a risk factor for incident CHD and whether it is correlated with increased platelet activation in a case-cohort study nested within a prospective epidemiologic investigation. Methods and Results-Blood samples were collected and processed from the Atherosclerosis Risk in Communities Study cohort at the baseline examination (1987 to 1989). They were stored at -80 degrees C, Pl(A1/A2) genotype and plasma beta-thromboglobulin levels were determined in 439 incident CHD casesand a reference cohort sample of 544 (of whom 18 were also CHD cases). Theprevalence of the Pl(A2) allele was not different in cases versus noncases, No significant correlation between CHD risk factors and the Pl(A2) allelewas noted either. Platelet activation, as measured by plasma beta-thromboglobulin levels, was not enhanced in individuals with the Pl(A2) allele. Conclusions-This prospective study indicates that healthy individuals carrying the Pl(A2) allele do not have an increased risk of CHD.

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Documento generato il 29/03/20 alle ore 15:02:47