Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of Ets-1 transcription factor is correlated with penetrating tumor progression in patients with squamous cell carcinoma of the esophagus
Autore:
Saeki, H; Kuwano, H; Kawaguchi, H; Ohno, S; Sugimachi, K;
Indirizzi:
Kyushu Univ, Fac Med, Dept Surg 2, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 d, Dept Surg 2, Fukuoka 8128582, Japan Gunma Univ, Fac Med, Dept Surg 1, Gunma, Japan Gunma Univ Gunma JapanGunma Univ, Fac Med, Dept Surg 1, Gunma, Japan
Titolo Testata:
CANCER
fascicolo: 8, volume: 89, anno: 2000,
pagine: 1670 - 1676
SICI:
0008-543X(20001015)89:8<1670:EOETFI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; PLASMINOGEN-ACTIVATOR; GENE; ONCOGENE; PROMOTER; INVASION; C-ETS-1; PROTEIN;
Keywords:
Ets-1; squamous cell carcinoma of the esophagus; heterogenicity; penetrating tumor progression; infiltrative invasive phenotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Saeki, H Kyushu Univ, Fac Med, Dept Surg 2, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 urg 2, Fukuoka 8128582, Japan
Citazione:
H. Saeki et al., "Expression of Ets-1 transcription factor is correlated with penetrating tumor progression in patients with squamous cell carcinoma of the esophagus", CANCER, 89(8), 2000, pp. 1670-1676

Abstract

BACKGROUND, The Ets-1 transcription factor is proposed to play a role in tumor invasion. To evaluate the biologic significance of Ets-1 in the progression of squamous cell carcinoma of the esophagus, the authors investigatedEts-1 expression in tumors from 90 patients using immunohistochemical procedures. METHODS. The Ets-1 positive ratio (Ets-1 ratio) was determined in the center and deep margin areas of invasive sites and in the center and outer edgeareas of intraepithelial spread contiguous with invasive disease. RESULTS. Ets-1 expression was heterogeneous within tumor tissue. The Ets-1ratio was significantly higher at invasive sites compared with intraepithelial spread sites, and at deep margin areas compared with center areas (P <0.0001 and P < 0.05, respectively, by two-way analysis of variance). No differences were noted in the Ets-1 ratio at the deep margin areas at each depth of invasion. Investigating the Ets-1 ratio at deep margin areas in eachpathologic phenotype, the ratio of the small nest type was found to be higher than that of the large nest type (P < 0.0001). CONCLUSIONS. The authors propose that Ets-1 plays an important role in penetrating tumor progression, even very early in the invasive process (especially in the case of infiltrative invasive type tumors) at the deep margin areas of invasive sites in patients with squamous cell carcinoma of the esophagus. Cancer 2000;89: 1670-6. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:45:48