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Titolo:
5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting
Autore:
Loewen, PS; Marra, CA; Zed, PJ;
Indirizzi:
Vancouver Hosp & Hlth Sci Ctr, CSU Pharmaceut Sci, Vancouver, BC V5Z 1M9, Canada Vancouver Hosp & Hlth Sci Ctr Vancouver BC Canada V5Z 1M9 V5Z 1M9, Canada Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada Univ British Columbia Vancouver BC Canada eut Sci, Vancouver, BC, Canada
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 10, volume: 47, anno: 2000,
pagine: 1008 - 1018
SICI:
0832-610X(200010)47:10<1008:5RAVTA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR GYNECOLOGICAL SURGERY; DOUBLE-BLIND; ANTIEMETIC EFFICACY; FEMALE-PATIENTS; LAPAROSCOPIC CHOLECYSTECTOMY; UNANTICIPATED ADMISSION; INTRAVENOUS DOLASETRON; AMBULATORY SURGERY; ONDANSETRON; DROPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Zed, PJ Vancouver Hosp & Hlth Sci Ctr, CSU Pharmaceut Sci, 855 West 12th Ave, Vancouver, BC V5Z 1M9, Canada Vancouver Hosp & Hlth Sci Ctr 855 West 12th Ave Vancouver BC Canada V5Z 1M9
Citazione:
P.S. Loewen et al., "5-HT3 receptor antagonists vs traditional agents for the prophylaxis of postoperative nausea and vomiting", CAN J ANAES, 47(10), 2000, pp. 1008-1018

Abstract

Purpose: Numerous antiemetics have been studied for the prevention of postoperative nausea and vomiting (PONV) including traditional agents (metoclopramide, perphenazine, prochlorperazine, cyclizine and droperidol) and the 5-HT receptor antagonists (ondansetron, dolasetron, granisetron and tropisetron). The results have been divergent and inconsistent. The purpose of thisquantitative systematic review was to evaluate the effectiveness of 5HT(3)receptor antagonists compared to traditional antiemetics for the prevention of PONV:Methods: A systematic search of the English language literature using computerized MEDLINE, EMBASE, and Pre-MEDLINE databases from 1966 to October 1999 and a manual search of references from retrieved articles were per formed, individual efficacy and adverse effect data was extracted from each of the studies according to a predefined protocol. The summary odds ratios werecalculated using the Dersimonian and Laird method under a random effects model. Results: A total of 41 trials met our pre-defined inclusion criteria and were included in our analysis. Results in the 32 studies examining PONV indicated a 46% reduction in the odds of PONV in the 5-HT3-treated group (0.54 [95% CI 0.42-0.71], P < 0.00 1). Evaluation of PONV by traditional antiemetic agent demonstrated a 39% reduction compared with droperidol (0.61 [95% CI 0.42-0.89], P < 0.00 1)and a 56% reduction compared with metoclopramide (0.44 [95% CI 0.31-0,62], P < 0.00 1). Results in the 34 studies examining vomiting indicated a 38% reduction in the odds of vomiting in the 5-HT3-treated group (0.62 [95% CI 0.48-0.81], P < 0.00 1). Conclusions: The 5-HT3 receptor antagonists are superior to traditional antiemetic agents for the prevention of PONV and vomiting. The reduction in the odds of PONV and vomiting is significant in the overall analysis and thesubgroup analyses comparing 5-HT3 receptor antagonists with droperidol andmetoclopramide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 00:18:44