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Titolo:
Intubating conditions and blockade after mivacurium, rocuronium and their combination in young and elderly adults
Autore:
Motamed, C; Donati, F;
Indirizzi:
CHU Montreal, Hotel Dieu, Dept Anesthesie, Montreal, PQ H2W 1T8, Canada CHU Montreal Montreal PQ Canada H2W 1T8 sie, Montreal, PQ H2W 1T8, Canada
Titolo Testata:
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
fascicolo: 3, volume: 47, anno: 2000,
pagine: 225 - 231
SICI:
0832-610X(200003)47:3<225:ICABAM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADDUCTOR POLLICIS MUSCLES; VECURONIUM NEUROMUSCULAR BLOCKADE; ORBICULARIS OCULI; TRACHEAL INTUBATION; D-TUBOCURARINE; DOSE-RESPONSE; ATRACURIUM; ONSET; SUXAMETHONIUM; DURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Donati, F CHU Montreal, Hotel Dieu, Dept Anesthesie, 3840 Rue St Urbain, Montreal, PQ H2W 1T8, Canada CHU Montreal 3840 Rue St Urbain Montreal PQ Canada H2W 1T8 anada
Citazione:
C. Motamed e F. Donati, "Intubating conditions and blockade after mivacurium, rocuronium and their combination in young and elderly adults", CAN J ANAES, 47(3), 2000, pp. 225-231

Abstract

Purpose: Mivacurium-rocuronium combinations have been demonstrated to be more potent than either drug given alone. Combinations were compared with mivacurium and rocuronium, with respect to onset, intubating conditions, and duration of action in young and elderly adults. Methods: Fentanyl-propofol-N2O-isoflurane anesthesia was given to ASA I and II adults aged 18-65 yr (45 patients) and over 66 yr (45 patients), In this blinded randomized study, we compared accelerographic adductor pollicis response and visual assessment of response to facial nerve stimulation after 0.25 mg.kg(-1) mivacurium, 0.6 mg.kg(-1) rocuronium, and a combination of0.08 mg.kg(-1) mivacurium plus 0.2 mg.kg(-1) rocuronium. Intubating conditions at 2.5 min were rated as excellent, good, fair or poor. Results: Onset times were similar for all drugs regimens and for both age groups (204-276 sec at the thumb; 142-196 sec at the eye) (P < 0.05 betweenmuscles). Intubating conditions were similar in all groups, and rated goodor excellent, except in two subjects, In young patients duration to 25% recovery was longer (P < 0.05) for rocuronium (mean +/- SD) (39 +/- 11 min) than for either mivacurium (23 +/- 6 min), or the combination (27 +/- 7 min). Duration was prolonged in the elderly for rocuronium (54 +/- 17 min), andthe combination ( 35 +/- 11 min), but not for mivacurium (24 +/- 6 min),Conclusions: Mivacurium-rocuronium combinations yield onset times and intubating conditions similar to either parent agent with only two thirds as much total drug. Duration for such a mixture is similar to that of mivacuriumin young adults and slightly prolonged in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:03:20