Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC-EVIDENCE FOR A TYROSINE KINASE CASCADE PRECEDING THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE IN VERTEBRATE G-PROTEIN SIGNALING
Autore:
WAN Y; BENCE K; HATA A; KUROSAKI T; VEILLETTE A; HUANG XY;
Indirizzi:
CORNELL UNIV,COLL MED,DEPT PHYSIOL NEW YORK NY 10021 CORNELL UNIV,COLL MED,DEPT PHYSIOL NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,HOWARD HUGHES MED INST NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,CELL BIOL PROGRAM NEW YORK NY 10021 KANSAI MED UNIV,DEPT MOL GENET MORIGUCHI OSAKA 570 JAPAN MCGILL UNIV,CTR CANC MONTREAL PQ H3G 1Y6 CANADA
Titolo Testata:
The Journal of biological chemistry
fascicolo: 27, volume: 272, anno: 1997,
pagine: 17209 - 17215
SICI:
0021-9258(1997)272:27<17209:GFATKC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GAMMA-SUBUNITS; RAS-DEPENDENT ACTIVATION; FOCAL ADHESION KINASE; B-CELL DEVELOPMENT; MAP KINASE; GROWTH-FACTOR; PERTUSSIS TOXIN; ANGIOTENSIN-II; LYSOPHOSPHATIDIC ACID; COUPLED RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
Y. Wan et al., "GENETIC-EVIDENCE FOR A TYROSINE KINASE CASCADE PRECEDING THE MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE IN VERTEBRATE G-PROTEIN SIGNALING", The Journal of biological chemistry, 272(27), 1997, pp. 17209-17215

Abstract

The signal transduction pathway from heterotrimeric G proteins to themitogen-activated protein kinase (MAPK) cascade is best understood inthe yeast mating pheromone response, in which a serine/threonine protein kinase (STE20) serves as the critical linking component, Little isknown in metazoans on how G proteins and the MAPK cascade are coupled, Here we provide genetic and biochemical evidence that a tyrosine kinase cascade bridges G proteins and the MAPK pathway in vertebrate cells, Targeted deletion of tyrosine kinase Csk in avian B lymphoma cells blocks the stimulation of MAPK by G(q), but not G(i)-, coupled receptors, In cells deficient in Bruton's tyrosine kinase (Btk), G(i)-coupledreceptors failed to activate MAPK, while G(q)-coupled receptor-mediated stimulation is unaffected. Taken together with our previous data ontyrosine kinases Lyn and Syk, the G(q)-coupled pathway requires tyrosine kinases Csk, Lyn, and Syk, while the G(i)-coupled pathway requirestyrosine kinases Btk and Syk to feed into the MAPK cascade in these cells, The central role of Syk is further strengthened by data showing that Syk can bind to purified Lyn, Csk, or Btk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 15:35:59